Fumagillin-induced aseptic meningoencephalitis in a kidney transplant recipient with microsporidiosis.

Abstract

Microsporidiosis is an opportunistic infection in organ transplant recipients and patients with other cellular immunodeficiency. Fumagillin is an effective treatment against Enterocytozoon bieneusi, one of the two main species causing the microsporidiosis involved in human diseases. We report the first case, to our knowledge, of a probable drug-induced aseptic meningoencephalitis, after administration of fumagillin in a kidney transplant recipient with microsporidiosis.

• Authors: A Audemard, M L Le Bellec, L Carluer, S Dargère, R Verdon, C Castrale, T Lobbedez, B Hurault de Ligny
• Journal: Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 14 Issue 6 Pg. E147-9 (Dec 2012) ISSN: 1399-3062 [Electronic] Denmark
• PMID: 23025483 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 John Wiley & Sons A/S.

Chemical References

• Antifungal Agents
• Cyclohexanes
• Fatty Acids, Unsaturated
• Sesquiterpenes
• fumagillin

Topics

• Antifungal Agents (adverse effects)
• Cyclohexanes (adverse effects, therapeutic use)
• Fatty Acids, Unsaturated (adverse effects, therapeutic use)
• Female
• Humans
• Immunocompromised Host
• Kidney Transplantation (adverse effects)
• Meningoencephalitis (etiology)
• Microsporidiosis (drug therapy)
• Middle Aged
• Sesquiterpenes (adverse effects, therapeutic use)