Fumagillin-induced aseptic meningoencephalitis in a kidney transplant recipient with microsporidiosis.

Microsporidiosis is an opportunistic infection in organ transplant recipients and patients with other cellular immunodeficiency. Fumagillin is an effective treatment against Enterocytozoon bieneusi, one of the two main species causing the microsporidiosis involved in human diseases. We report the first case, to our knowledge, of a probable drug-induced aseptic meningoencephalitis, after administration of fumagillin in a kidney transplant recipient with microsporidiosis.
AuthorsA Audemard, M L Le Bellec, L Carluer, S Dargère, R Verdon, C Castrale, T Lobbedez, B Hurault de Ligny
JournalTransplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 14 Issue 6 Pg. E147-9 (Dec 2012) ISSN: 1399-3062 [Electronic] Denmark
PMID23025483 (Publication Type: Case Reports, Journal Article)
Copyright© 2012 John Wiley & Sons A/S.
Chemical References
  • Antifungal Agents
  • Cyclohexanes
  • Fatty Acids, Unsaturated
  • Sesquiterpenes
  • fumagillin
  • Antifungal Agents (adverse effects)
  • Cyclohexanes (adverse effects, therapeutic use)
  • Fatty Acids, Unsaturated (adverse effects, therapeutic use)
  • Female
  • Humans
  • Immunocompromised Host
  • Kidney Transplantation (adverse effects)
  • Meningoencephalitis (etiology)
  • Microsporidiosis (drug therapy)
  • Middle Aged
  • Sesquiterpenes (adverse effects, therapeutic use)

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