Abstract | BACKGROUND: CASE DESCRIPTION: The authors present a case of a 16-year-old girl who had a diagnosis of MEN 2B and was treated successfully for metastatic MTC. CLINICAL IMPLICATIONS: Given the striking orofacial manifestations of MEN 2B (marfanoid habitus; dolichocephaly; everted and thickened lips; mucosal neuromas on lips, tongue, buccal mucosa and eyelids), dental professionals are well positioned to recognize the disorder. Early identification of patients with the condition permits screening for preclinical thyroid disease, molecular genetic testing, counseling and lifesaving thyroid surgery.
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Authors | Joanne M Collins, Shahid I Chaudhry, Daljit S Gill, Stephen R Porter |
Journal | Journal of the American Dental Association (1939)
(J Am Dent Assoc)
Vol. 143
Issue 10
Pg. 1093-8
(Oct 2012)
ISSN: 1943-4723 [Electronic] England |
PMID | 23024306
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Calcitonin
- Proto-Oncogene Proteins c-ret
|
Topics |
- Adolescent
- Adrenal Gland Neoplasms
(diagnosis)
- Calcitonin
(metabolism)
- Facies
- Female
- Head and Neck Neoplasms
(metabolism, radiotherapy, surgery)
- Humans
- Malocclusion, Angle Class II
(complications)
- Mouth Neoplasms
(diagnosis)
- Multiple Endocrine Neoplasia
(complications, diagnosis, genetics, surgery)
- Mutation, Missense
- Neck Dissection
- Neuroma
(diagnosis)
- Pheochromocytoma
(diagnosis)
- Proto-Oncogene Proteins c-ret
(genetics)
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