Chronotherapeutics--a chronopharmaceutical approach to drug delivery in the treatment of asthma.

Bronchial asthma is a chronic inflammatory disorder of the airways associated with airflow obstruction that is reversible spontaneously or with treatment. Bronchial asthma is a disease based on established circadian rhythm. The symptoms of asthma worsen during midnight to early morning and therefore it is required to deliver the drug in such fashion that effective treatment can be obtained during the time of asthma attacks. Chronotherapy is an approach that fulfills the criteria of drug delivery at a specific time as per the pathophysiological need of the disease, to improve patient compliance. The current article focuses on the chronotherapy of bronchial asthma, methodologies involved for the existing systems, recent updates and different chronopharmaceutical technologies currently available in the market. Chronotherapy with different categories of bronchial asthma medications also has been reviewed.
AuthorsNidhi Nainwal
JournalJournal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 163 Issue 3 Pg. 353-60 (Nov 10 2012) ISSN: 1873-4995 [Electronic] Netherlands
PMID23022979 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2012 Elsevier B.V. All rights reserved.
Chemical References
  • Adrenergic beta-2 Receptor Antagonists
  • Anti-Asthmatic Agents
  • Glucocorticoids
  • Leukotriene Antagonists
  • Theophylline
  • Adrenergic beta-2 Receptor Antagonists (administration & dosage)
  • Anti-Asthmatic Agents (administration & dosage)
  • Asthma (drug therapy)
  • Drug Chronotherapy
  • Glucocorticoids (administration & dosage)
  • Humans
  • Leukotriene Antagonists (administration & dosage)
  • Theophylline (administration & dosage)

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