Abstract | CONTEXT: OBJECTIVE: DESIGN: Interventional, randomised, double-blinded, placebo-controlled study to evaluate a preoperative single dose of dexamethasone. SETTING: Patients from a tertiary hospital in the city of Sao Paulo, Sao Paulo, Brazil observed from 1 January through 30 June 2008. PATIENTS OR OTHER PARTICIPANTS: Seventy full-term pregnant patients (American Society of Anesthesiologists 1 or 2) were studied. Patients were randomly allocated into two groups determined by a computerised table. Exclusion criteria were contraindication to regional anaesthesia, allergy to dexamethasone, opioids or local anaesthetics, hypertension or diabetes originated during pregnancy and use of any antiemetic drug received before surgery. Spinal anaesthesia consisted of hyperbaric bupivacaine and morphine. INTERVENTION: Patients received either dexamethasone 10 mg in 100 ml of isotonic saline, intravenously or 100 ml of isotonic saline (placebo) prior to surgery. MAIN OUTCOME: RESULTS: During the first 24 hours, nausea occurred in 12/35 (34.4%) patients receiving dexamethasone and in 32/35 (91.4%) receiving placebo (P<0.001). During the same time period, vomiting occurred in 12/35 (34.4%) patients receiving dexamethasone and in 29/35 (82.9%) receiving placebo (P<0.001). Pain at rest and pain on movement was lower in patients who received dexamethasone at some time points during the study period. CONCLUSION:
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Authors | Monica M S Cardoso, Alexandre O Leite, Elisa A Santos, Judymara L Gozzani, Lígia A S T Mathias |
Journal | European journal of anaesthesiology
(Eur J Anaesthesiol)
Vol. 30
Issue 3
Pg. 102-5
(Mar 2013)
ISSN: 1365-2346 [Electronic] England |
PMID | 23022704
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiemetics
- Morphine
- Dexamethasone
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Topics |
- Adult
- Anesthesia, Spinal
(methods)
- Antiemetics
(administration & dosage)
- Brazil
- Cesarean Section
(methods)
- Dexamethasone
(administration & dosage)
- Double-Blind Method
- Female
- Humans
- Morphine
(administration & dosage)
- Pain, Postoperative
(prevention & control)
- Postoperative Complications
- Postoperative Nausea and Vomiting
(prevention & control)
- Pregnancy
- Time Factors
- Vomiting
(prevention & control)
- Young Adult
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