[Use of botulinum toxin in a patient with pendular congenital nystagmus].

We report the case of a 5 month-old male diagnosed with congenital nystagmus and oculocutaneous albinism. The initial examination showed pendular horizontal nystagmus with high amplitude and without blocking position or foveal fixation periods. A 2.5 IU injection of botulinum toxin was administered in the horizontal rectus muscles of both eyes in two sessions separated by 6 weeks. This led to a decrease in amplitude of nystagmus and early development of binocular visual acuity of 4.8cycles/cm.
Faced with diagnosis of horizontal nystagmus in the early stages of development, and in order to avoid periods of foveal fixation, the use of botulinum toxin leads to a temporary reduction in its amplitude and an improvement in visual acuity with low complication rates. Given the possibility of spontaneous improvement described in these patients, studies are needed with longer follow-up to establish the advantage of long term treatment.
AuthorsE Hernández-García, R Gómez-De-Liaño-Sánchez
JournalArchivos de la Sociedad Española de Oftalmología (Arch Soc Esp Oftalmol) Vol. 87 Issue 10 Pg. 330-2 (Oct 2012) ISSN: 1989-7286 [Electronic] Spain
Vernacular TitleEmpleo de toxina botulínica en paciente con nistagmus congénito de tipo pendular.
PMID23021231 (Publication Type: Case Reports, English Abstract, Journal Article)
CopyrightCopyright © 2010 Sociedad Española de Oftalmología. Published by Elsevier Espana. All rights reserved.
Chemical References
  • Neuromuscular Agents
  • Botulinum Toxins, Type A
  • Albinism, Oculocutaneous (complications)
  • Botulinum Toxins, Type A (therapeutic use)
  • Humans
  • Infant
  • Male
  • Neuromuscular Agents (therapeutic use)
  • Nystagmus, Congenital (drug therapy)
  • Nystagmus, Pathologic (drug therapy)
  • Treatment Outcome
  • Vision, Binocular
  • Visual Acuity

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