Intestinal amyloidosis with intractable diarrhea and intestinal pseudo-obstruction.

Abstract

We report herein a case of intestinal amyloidosis with grave prognosis that caused intractable diarrhea and intestinal pseudo-obstruction, alternately in spite of intensive conservative treatment. A 44-year-old woman was admitted for fever, diarrhea, and crampy abdominal pain which had been continuned during 6 months. Abdomen CT scan showed edematous wall thickening of the small bowel and right colon, and colonoscopic biopsy revealed amyloid deposition in the mucosa. Monoclonal light chains in serum and/or urine were not detected and highly elevated serum amyloid A was shown. In spite of intensive treatment including oral prednisolone and colchicine, diarrhea and intestinal pseudo-obstruction developed alternately, general status rapidly got worsened and died after two months.

• Authors: Yeon-Joo Kim, Hyun-Soo Kim, Seon-Young Park, Sang-Woo Park, Yoo-Duk Choi, Chang-Hwan Park, Sung-Kyu Choi, Jong-Sun Rew
• Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi (Korean J Gastroenterol) Vol. 60 Issue 3 Pg. 172-6 (Sep 25 2012) ISSN: 2233-6869 [Electronic] Korea (South)
• PMID: 23018539 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Serum Amyloid A Protein
• Tubulin Modulators
• Prednisolone
• Colchicine

Topics

• Administration, Oral
• Adult
• Amyloidosis (complications, diagnosis, drug therapy)
• Anti-Inflammatory Agents (therapeutic use)
• Colchicine (therapeutic use)
• Colonoscopy
• Diarrhea (etiology)
• Female
• Humans
• Intestinal Mucosa (pathology)
• Intestinal Pseudo-Obstruction (diagnosis, etiology)
• Prednisolone (therapeutic use)
• Serum Amyloid A Protein (metabolism)
• Tomography, X-Ray Computed
• Tubulin Modulators (therapeutic use)