Collagenase for Dupuytren's disease of the thumb.

Abstract

Injectable collagenase is an alternative to surgical treatment for Dupuytren's disease. Previous studies have reported on the effectiveness of collagenase in finger contractures. This prospective study reports on the short-term safety and efficacy of collagenase treatment in five thumb and first web space Dupuytren's contractures. The thumb and first web space contractures were treated with injectable collagenase in four consecutive patients (five hands) with experience of previous surgical digital fasciectomy. The thumb contracture was measured by angle and span in two planes of thumb extension and abduction before injection and after manipulation. Collagenase treatment resulted in release of the contracture with a mean increase in thumb to index angle from 23° (10° to 35°) to 56° (45° to 60°) in extension and from 30° (10° to 50°) to 58° (50° to 65°) in abduction and a mean increase in span from 1.9 cm (1 to 3.5) to 3.9 cm (3 to 5) in extension and from 2.4 cm (1.5 to 3.5) to 3.9 cm (3 to 4.5) in abduction. All patients reported an increased range of movement and function and described collagenase therapy as preferable to surgery. In the short-term collagenase is an effective, well-tolerated and safe alternative to surgery for Dupuytren's disease of the thumb.

• Authors: C L Bendon, H P Giele
• Journal: The Journal of bone and joint surgery. British volume (J Bone Joint Surg Br) Vol. 94 Issue 10 Pg. 1390-2 (Oct 2012) ISSN: 2044-5377 [Electronic] England
• PMID: 23015566 (Publication Type: Journal Article)

Chemical References

• Collagenases
• xiapex

Topics

• Aged
• Collagenases (administration & dosage)
• Dupuytren Contracture (drug therapy)
• Female
• Humans
• Injections, Intralesional
• Male
• Middle Aged
• Prospective Studies
• Thumb