Collagen cross-linking for resistant corneal ulcer.

Abstract

Corneal ulcer is a devastating corneal disease which is potentially sight-threatening and conventionally is treated by topical antibiotics and in some cases with more invasive procedures such as keratoplasty. The aim of this study is to evaluate the efficacy of corneal collagen cross-linking in resistant corneal ulcers. Ten patients with resistant infectious corneal ulcers who had not responded properly to maximal treatment with topical and subconjunctival antibiotics were enrolled in the study and underwent classic corneal collagen cross-linking with riboflavin and UV-A under sterile conditions in the operating room and were followed up regularly. The result was healing and scar formation with improvement of vision in all patients except for two who underwent enucleation and tectonic penetrating keratoplasty. Corneal collagen cross-linking is a viable therapeutic option for treatment of corneal ulcers and can be used as an adjuvant for conventional treatment in resistant cases.

• Authors: Rana Sorkhabi, Mohamadreza Sedgipoor, Ali Mahdavifard
• Journal: International ophthalmology (Int Ophthalmol) Vol. 33 Issue 1 Pg. 61-6 (Feb 2013) ISSN: 1573-2630 [Electronic] Netherlands
• PMID: 23015020 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cross-Linking Reagents
• Collagen

Topics

• Administration, Topical
• Adolescent
• Adult
• Aged
• Collagen (administration & dosage, therapeutic use)
• Corneal Ulcer (diagnosis, drug therapy, physiopathology)
• Cross-Linking Reagents (administration & dosage, therapeutic use)
• Eye Infections, Bacterial (diagnosis, drug therapy, physiopathology)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Treatment Outcome
• Visual Acuity
• Young Adult