Anti-inflammatory activities of fractions from Geranium nepalense and related polyphenols.

Abstract

Geranium nepalense Sweet is a common Chinese herbal medicine and has been used as influenza, dysentery, antiphlogistic and analgesic tonic, hemostatic, stomachic, and antidiabetic drugs. The anti-inflammatory effects of G. nepalense on tetradecanoyl phorbol acetate (TPA)-induced mouse ear edema were studied in this work. The results showed that ethyl acetate fraction of the water extract of G. nepalense possessed significant activity at 2.5 g/kg (p < 0.01) with aspirin as a positive control (0.6 g/kg). Six polyphenolic compounds, including three flavonoids, i.e. kaempferol, kaempferol-7-O-β-D-glucopyranoside, and quercetin-7-O-α-rhamnopyranoside, and two tannins, i.e. pyrogallol and gallic acid, and one lignin, i.e. epipinoresinol, were isolated and characterized from ethyl acetate fraction. The isolation of polyphenols provides a clue for beneficial effects of G. nepalense in the demonstrated anti-inflammatory activity.

• Authors: C H Lu, Y Y Li, L J Li, L Y Liang, Y M Shen
• Journal: Drug discoveries & therapeutics (Drug Discov Ther) Vol. 6 Issue 4 Pg. 194-7 (Aug 2012) ISSN: 1881-7831 [Print] Japan
• PMID: 23006989 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Drugs, Chinese Herbal
• Polyphenols

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (isolation & purification, pharmacology, therapeutic use)
• Disease Models, Animal
• Drugs, Chinese Herbal (isolation & purification, pharmacology, therapeutic use)
• Edema (drug therapy)
• Geranium (chemistry)
• Mice
• Mice, Inbred Strains
• Molecular Structure
• Polyphenols (isolation & purification, pharmacology, therapeutic use)
• Treatment Outcome