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Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi.

AbstractBACKGROUND:
There have been few clinical studies of the role of regulatory T cells (Tregs) in halo formation of halo nevus.
OBJECTIVE:
To evaluate the clinicopathologic features and the presence of Tregs in halo nevi.
METHODS:
We analyzed 30 halo nevi and performed immunohistochemical analysis using antibodies against CD4, CD8, CD25 and Foxp3. We also performed double immunohistochemical staining for Foxp3 and CD25.
RESULTS:
We found significant increases in Foxp3(+) Tregs, and the shorter the halo nevus duration, the more Foxp3(+) Tregs were detected. Also, the ratio of Foxp3 to CD8 T cells was increased in early stages of halo nevi. Double immunohistochemical staining suggested that the Tregs in the halo nevi were CD25(+)Foxp3(+) T cells.
CONCLUSIONS:
Foxp3(+) Tregs were greatly increased in the halo nevi. The shorter the halo nevi duration, the more Foxp3(+) Tregs were involved in the earlier developmental stages of halo nevi.
AuthorsH S Park, S A Jin, Y-D Choi, M-H Shin, S E Lee, S J Yun
JournalDermatology (Basel, Switzerland) (Dermatology) Vol. 225 Issue 2 Pg. 172-8 ( 2012) ISSN: 1421-9832 [Electronic] Switzerland
PMID23006793 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 S. Karger AG, Basel.
Chemical References
  • CD4 Antigens
  • FOXP3 protein, human
  • Forkhead Transcription Factors
Topics
  • Adolescent
  • Adult
  • CD4 Antigens (immunology)
  • Child
  • Female
  • Forkhead Transcription Factors (immunology)
  • Humans
  • Male
  • Middle Aged
  • Nevus, Halo (immunology, pathology)
  • Skin Neoplasms (immunology, pathology)
  • T-Lymphocytes, Regulatory (immunology)
  • Young Adult

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