Abstract | BACKGROUND: There have been few clinical studies of the role of regulatory T cells (Tregs) in halo formation of halo nevus. OBJECTIVE: To evaluate the clinicopathologic features and the presence of Tregs in halo nevi. METHODS: We analyzed 30 halo nevi and performed immunohistochemical analysis using antibodies against CD4, CD8, CD25 and Foxp3. We also performed double immunohistochemical staining for Foxp3 and CD25. RESULTS: We found significant increases in Foxp3(+) Tregs, and the shorter the halo nevus duration, the more Foxp3(+) Tregs were detected. Also, the ratio of Foxp3 to CD8 T cells was increased in early stages of halo nevi. Double immunohistochemical staining suggested that the Tregs in the halo nevi were CD25(+)Foxp3(+) T cells. CONCLUSIONS: Foxp3(+) Tregs were greatly increased in the halo nevi. The shorter the halo nevi duration, the more Foxp3(+) Tregs were involved in the earlier developmental stages of halo nevi.
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Authors | H S Park, S A Jin, Y-D Choi, M-H Shin, S E Lee, S J Yun |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 225
Issue 2
Pg. 172-8
( 2012)
ISSN: 1421-9832 [Electronic] Switzerland |
PMID | 23006793
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- CD4 Antigens
- FOXP3 protein, human
- Forkhead Transcription Factors
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Topics |
- Adolescent
- Adult
- CD4 Antigens
(immunology)
- Child
- Female
- Forkhead Transcription Factors
(immunology)
- Humans
- Male
- Middle Aged
- Nevus, Halo
(immunology, pathology)
- Skin Neoplasms
(immunology, pathology)
- T-Lymphocytes, Regulatory
(immunology)
- Young Adult
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