Abstract | BACKGROUND: METHODS: RESULTS: The concentration of serum IL-33 was significantly higher in patients with AEP than in CEP. In CEP, only patients with atopic factors showed mild increase of serum IL-33. The concentration of BALF IL-33 was also significantly elevated in AEP, however, it remained quite low in CEP. Among Th2 cytokines, IL-5 was significantly increased in both serum and BALF in AEP, and the level of IL-5 was positively correlated with that of IL-33. ARDS showed no increase of serum and BALF IL-33. CONCLUSIONS: The remarkable increase of BALF IL-33 in AEP indicated the local production of IL-33 in lungs. IL-33 is considered to be a local key molecule for triggering pulmonary eosinophilia, together with IL-5. BALF IL-33 appears to be a useful marker for discriminating AEP from CEP and ARDS.
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Authors | Naoko Mato, Masashi Bando, Aya Kusano, Toshikatsu Hirano, Masayuki Nakayama, Tomohiro Uto, Takakiyo Nakaya, Hideaki Yamasawa, Yukihiko Sugiyama |
Journal | Allergology international : official journal of the Japanese Society of Allergology
(Allergol Int)
Vol. 62
Issue 1
Pg. 45-52
(Mar 2013)
ISSN: 1440-1592 [Electronic] England |
PMID | 23000728
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Cytokines
- IL33 protein, human
- Interleukin-33
- Interleukins
- Immunoglobulin E
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Topics |
- Adult
- Aged
- Biomarkers
(blood, metabolism)
- Bronchoalveolar Lavage Fluid
(chemistry, immunology)
- Cytokines
(immunology, metabolism)
- Female
- Humans
- Immunoglobulin E
(blood, immunology)
- Interleukin-33
- Interleukins
(blood, metabolism)
- Male
- Middle Aged
- Pulmonary Eosinophilia
(immunology, metabolism)
- Respiratory Distress Syndrome
(immunology, metabolism)
- Th2 Cells
(immunology, metabolism)
- Young Adult
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