Polymorphisms of catechol estrogens metabolism pathway genes and breast cancer risk in Mexican women.

Abstract	Breast cancer is associated to estrogen exposure. Allelic variants involved in estrogen metabolism might change the risk of developing this neoplasia. We examined the potential association of breast cancer risk in Mexican women with the polymorphisms CYP1A1 rs1048943, CYP1B1 rs1056836, COMT rs4680, GSTP1 rs1695, GSTT1 null and GSTM1 null which are involved in estrogen metabolism pathway. This study included 150 cases and 150 controls. A significant association was observed between, CYP1A1 rs1048943 (OR = 1.95, C.I. 1.13-3.36) and GSTP1 rs1695 (OR = 2.39, C.I. 1.24-4.24) polymorphisms with the risk of breast cancer. This risk was increased when the women were stratified according to their menopausal status. The results show that breast cancer risk significantly increases in women with 3-6 risk polymorphisms (OR = 3.75, C.I. 1.44-9.74).
Authors	O C Martínez-Ramírez, R Pérez-Morales, C Castro, A Flores-Díaz, K E Soto-Cruz, A Astorga-Ramos, M E Gonsebatt, L Casas, M Valdés-Flores, J Rubio
Journal	Breast (Edinburgh, Scotland) (Breast) Vol. 22 Issue 3 Pg. 335-43 (Jun 2013) ISSN: 1532-3080 [Electronic] Netherlands
PMID	23000097 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References	Estrogens, Catechol Aryl Hydrocarbon Hydroxylases CYP1A1 protein, human CYP1B1 protein, human Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1B1 Catechol O-Methyltransferase glutathione S-transferase T1 GSTP1 protein, human Glutathione S-Transferase pi Glutathione Transferase glutathione S-transferase M1
Topics	Adult Aged Aryl Hydrocarbon Hydroxylases (genetics) Breast Neoplasms (genetics, metabolism) Case-Control Studies Catechol O-Methyltransferase (genetics) Cytochrome P-450 CYP1A1 (genetics) Cytochrome P-450 CYP1B1 Estrogens, Catechol (metabolism) Female Genotype Glutathione S-Transferase pi (genetics) Glutathione Transferase (genetics) Humans Menopause (metabolism) Mexico Middle Aged Polymorphism, Genetic Retrospective Studies Risk Factors Signal Transduction (genetics)

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