Abstract | OBJECTIVE: METHODS: Fifty male Wistar rats were randomly allocated into 3 groups: sham operation group, in which animals underwent laparotomy, experimental group and control group in which were treated with 70% IRI of the liver, especially, the animals in experimental group was given intraperitoneal injection of 2 mL Ligustrazine per day for 3 days before operation. After the operation, liver tissues were harvested at 1 h, 6 h, 24 h and 72 h for the study of histomorphological change, the respiratory control ratio (RCR) and phosphorus: oxygen ratio (P/O) of hepatocytes mitochondria, and the contents of adenosine triphosphate ( ATP) of liver tissue. RESULTS: (1) The damage hepatic tissue in experimental group was slighter than that in control group at each corresponding time-point after operation. (2) The RCR and P/O ratio at each corresponding time-point were higher in experimental group than those in control group (P < 0.05), and all of the two groups recovered after 72 h. (3) The ATP concentration in experimental group also was higher than that in control group at each corresponding time-point, and recovered faster than control group. CONCLUSION:
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Authors | Zhu-Lin Luo, Fu-Zhou Tian, Li-Jun Tang, Tao Wang, Jian-Dong Ren, Hong-Tao Yan, Zhu Huang, Hua Wan |
Journal | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
(Sichuan Da Xue Xue Bao Yi Xue Ban)
Vol. 43
Issue 4
Pg. 540-2, 546
(Jul 2012)
ISSN: 1672-173X [Print] China |
PMID | 22997892
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Pyrazines
- tetramethylpyrazine
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Topics |
- Animals
- Energy Metabolism
(drug effects)
- Ischemic Preconditioning
(methods)
- Liver
(drug effects, metabolism, pathology)
- Male
- Pyrazines
(pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Reperfusion Injury
(prevention & control)
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