Abstract |
Alkali production by oral bacteria is believed to have a major impact on oral microbial ecology and to be inhibitory to the initiation and progression of dental caries. A substantial body of evidence is beginning to accumulate that indicates the modulation of the alkalinogenic potential of dental biofilms may be a promising strategy for caries control. This brief review highlights recent progress toward understanding molecular genetic and physiologic aspects of important alkali-generating pathways in oral bacteria, and the role of alkali production in the ecology of dental biofilms in health and disease.
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Authors | Ya-Ling Liu, Marcelle Nascimento, Robert A Burne |
Journal | International journal of oral science
(Int J Oral Sci)
Vol. 4
Issue 3
Pg. 135-40
(Sep 2012)
ISSN: 1674-2818 [Print] India |
PMID | 22996271
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Alkalies
- Agmatine
- Arginine
- Hydrolases
- Urease
- arginine deiminase
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Topics |
- Agmatine
(metabolism)
- Alkalies
(metabolism)
- Arginine
(metabolism)
- Dental Caries
(prevention & control)
- Dental Plaque
(enzymology, metabolism, microbiology)
- Humans
- Hydrogen-Ion Concentration
- Hydrolases
(metabolism)
- Urease
(metabolism)
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