Association between XPD Asp312Asn polymorphism and esophageal cancer susceptibility: a meta-analysis.

Abstract

OBJECTIVE:

To investigate the association between xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism and esophageal cancer (EC) susceptibility by meta-analysis.

METHODS:

We searched PubMed up to April 9th, 2012, to identify relevant papers, and 8 published case-control studies including 2165 EC patients and 3141 healthy controls were yielded. Odds ratios (ORs) with relevant 95% confidence intervals (CIs) were applied to assess the association between XPD Asp312Asn polymorphism and EC susceptibility with the Comprehensive Meta-Analysis software, version 2.2.

RESULTS:

Overall, the meta-analysis results suggested the XPD Asp312Asn polymorphism to be significantly associated with EC susceptibility [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.20, 95%CI=1.05-1.36, p=0.01; and Asp/Asn vs. Asp/Asp: OR=1.15, 95%CI=1.01-1.31, p=0.04]. In the subgroup analysis by ethnicity and cancer type, significantly associations were found for Caucasian populations [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.26, 95%CI=1.08-1.47, p<0.001; Asp/Asn vs. Asp/Asp: OR=1.19, 95%CI=1.02- 1.40, p=0.03] and esophageal squamous cell carcinoma [(Asn/Asn+Asp/Asn) vs. Asp/Asp: OR=1.19, 95%CI=1.01-1.41, p=0.04]. There was no heterogeneity and no publication bias existed.

CONCLUSIONS:

This meta-analysis shows that the XPD Asp312Asn polymorphism may be a risk factor for developing EC, especially for Caucasian populations and esophageal squamous cell carcinoma.

• Authors: Xiao-Li Duan, Heng Gong, Xian-Tao Zeng, Xiao-Bing Ni, Yan Yan, Wen Chen, Guo-Lei Liu
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 7 Pg. 3299-303 ( 2012) ISSN: 2476-762X [Electronic] Thailand
• PMID: 22994751 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Xeroderma Pigmentosum Group D Protein
• ERCC2 protein, human

Topics

• Carcinoma, Squamous Cell (genetics)
• Case-Control Studies
• Esophageal Neoplasms (genetics)
• Genetic Predisposition to Disease
• Genotype
• Humans
• Odds Ratio
• Polymorphism, Single Nucleotide
• Risk Factors
• White People (genetics)
• Xeroderma Pigmentosum Group D Protein (genetics)