Abstract | AIMS: METHODS: Sixty-one hepatic tumours were categorised into 20 'definite' FNHs, 13 'probable' FNHs, and 28 cases without specific diagnosis. Needle biopsy specimens of 92 non-tumourous lesions, 25 well-differentiated hepatocellular carcinomas (WDHCCs), and 4 high-grade dysplastic nodules (HGDNs) and resection specimens of 10 macroregenerative nodules were also selected for immunohistochemical stain of GS for comparison. RESULTS: All 20 'definite' FNHs, nine 'probable' FNHs, and five cases without specific diagnosis expressed typical map-like staining pattern of GS. The demographic data of these five cases were similar to those of FNH. All cases of chronic hepatitis B and C, cirrhosis, macroregenerative nodule and peritumourous liver tissue showed normal pericentral/periseptal pattern. Fifteen of 25 WDHCCs and one HGDN showed diffuse pattern. Ten WDHCCs and two HGDNs showed negative staining. One HGDN showed mosaic pattern. CONCLUSIONS: Immunohistochemical staining of GS increases the diagnostic sensitivity of FNH in needle biopsy, especially in those without typical morphology. It also helps in differentiating FNH from other tumourous and non-tumourous lesions.
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Authors | J H Tsai, Y M Jeng, C C Pan, S W Lu, Y J Kuo |
Journal | Pathology
(Pathology)
Vol. 44
Issue 7
Pg. 605-10
(Dec 2012)
ISSN: 1465-3931 [Electronic] England |
PMID | 22990279
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Glutamate-Ammonia Ligase
|
Topics |
- Adult
- Aged
- Biomarkers, Tumor
(metabolism)
- Biopsy, Needle
- Carcinoma, Hepatocellular
(diagnosis, enzymology, pathology)
- Diagnosis, Differential
- Female
- Focal Nodular Hyperplasia
(diagnosis, enzymology, pathology)
- Glutamate-Ammonia Ligase
(metabolism)
- Humans
- Immunohistochemistry
- Liver Neoplasms
(diagnosis, enzymology, pathology)
- Male
- Middle Aged
- Precancerous Conditions
(enzymology, pathology)
- Young Adult
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