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Clinical evaluation of an in-office desensitizing paste containing 8% arginine and calcium carbonate for relief of dentin hypersensitivity prior to dental prophylaxis.

AbstractPURPOSE:
To evaluate the clinical efficacy of a professional prophylaxis paste containing 8% arginine-calcium carbonate in the reduction of dentin hypersensitivity used as a pre-procedural application compared to a commercially-available prophylaxis paste.
METHODS:
This study was conducted at Jersey Shore University Medical Center in Neptune, New Jersey, USA. A mixed population of adult males and females between the ages of 18-70 were included in the study. Baseline air blast hypersensitivity score of 2 or 3 (Schiff Cold Air Sensitivity Scale) were mandatory for inclusion in this study. Subjects were randomly assigned to either: (1) Control paste, Nupro non-fluoridated pumice based prophylaxis paste (Dentsply Professional) or (2) Test paste, a desensitizing paste containing 8% arginine and calcium carbonate (Colgate-Palmolive Company). Either the Control or Test paste was applied to subjects prior to their receiving a routine dental prophylaxis. After completion of the dental cleaning procedure, a final post-cleaning air blast examination was performed on each subject following identical methods as at the baseline exam. Paired t-tests and ANCOVA were used.
RESULTS:
66 subjects were enrolled in the study. Following the post-cleaning air blast hypersensitivity examination, there was a significant decrease of 83.94% in the hypersensitivity of subjects using the Test paste. The group using the Control paste showed a 13.43% desensitization. There was a statistically significant difference of 79.65% between the two groups. Subjects in the age groups 41-50, 51-60, and 61-70 years of age showed the most reduction in dentin hypersensitivity.
AuthorsWellington S Tsai, Sally-Jo Placa, Fotinos S Panagakos
JournalAmerican journal of dentistry (Am J Dent) Vol. 25 Issue 3 Pg. 165-70 (Jun 2012) ISSN: 0894-8275 [Print] United States
PMID22988687 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Dentin Desensitizing Agents
  • Drug Combinations
  • Arginine
  • Calcium Carbonate
Topics
  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Analysis of Variance
  • Arginine (therapeutic use)
  • Calcium Carbonate (therapeutic use)
  • Dental Prophylaxis
  • Dentin Desensitizing Agents (therapeutic use)
  • Dentin Sensitivity (drug therapy)
  • Drug Combinations
  • Female
  • Humans
  • Male
  • Middle Aged
  • Young Adult

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