Involvement of Src in the Adaptation of Cancer Cells under Microenvironmental Stresses.

Abstract

Protein-tyrosine phosphorylation, which is catalyzed by protein-tyrosine kinase (PTK), plays a pivotal role in a variety of cellular functions related to health and disease. The discovery of the viral oncogene Src (v-Src) and its cellular nontransforming counterpart (c-Src), as the first example of PTK, has opened a window to study the relationship between protein-tyrosine phosphorylation and the biology and medicine of cancer. In this paper, we focus on the roles played by Src and other PTKs in cancer cell-specific behavior, that is, evasion of apoptosis or cell death under stressful extracellular and/or intracellular microenvironments (i.e., hypoxia, anoikis, hypoglycemia, and serum deprivation).

• Authors: A K M Mahbub Hasan, Takashi Ijiri, Ken-Ichi Sato
• Journal: Journal of signal transduction (J Signal Transduct) Vol. 2012 Pg. 483796 ( 2012) ISSN: 2090-1747 [Electronic] United States
• PMID: 22988500 (Publication Type: Journal Article)