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Murine spontaneous T-cell leukemia constitutively expressing IL-2 receptor--a model for human T-cell malignancies expressing IL-2 receptor.

Abstract
We describe a new, spontaneously occurring BALB/c-derived murine T-cell leukemia. The leukemic cells, designated LB, grow rapidly and progressively in the syngeneic host with no signs of effective immunological resistance. LB cells expressed the Thy-1+, Lyt-2+, L3T4-, CD3- class-I+, CD25+ (IL-2 receptor, IL-2R), class-II-, gp70- phenotype. As LB cells express IL-2, as indicated by staining with 2 distinct anti-CD25 IL-2R monoclonal antibodies (MAbs), the therapeutic efficacy of IL-2-diphtheria toxin-related protein was tested on this leukemic model. IL-2-diphtheria toxin, but not diphtheria toxin, efficiently inhibited the proliferation of LB cells. The proliferation of a murine myeloma cell line, which does not express IL-2R, was not inhibited by IL-2-diphtheria toxin. The possible implantation of this animal model in fundamental and practical studies is discussed.
AuthorsH Lugasi, S Hajos, J R Murphy, T B Strom, J Nichols, C Peñarroja, D Naor
JournalInternational journal of cancer (Int J Cancer) Vol. 45 Issue 1 Pg. 163-7 (Jan 15 1990) ISSN: 0020-7136 [Print] United States
PMID2298500 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Antibodies, Monoclonal
  • Diphtheria Toxin
  • Interleukin-2
  • Receptors, Interleukin-2
  • Recombinant Fusion Proteins
  • interleukin 2-diphtheria toxin
Topics
  • Animals
  • Antibodies, Monoclonal
  • Cell Division
  • Cell Line (pathology)
  • Cell Separation
  • Diphtheria Toxin (therapeutic use)
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Female
  • Flow Cytometry
  • Humans
  • Interleukin-2 (therapeutic use)
  • Leukemia, T-Cell (immunology, pathology, therapy)
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Interleukin-2 (immunology)
  • Recombinant Fusion Proteins (therapeutic use)
  • Tumor Cells, Cultured (pathology)

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