High levels of immunoglobulin E autoantibody to 14-3-3 epsilon protein correlate with protection against severe Plasmodium falciparum malaria.
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| Abstract |
Plasmodium falciparum infection generally induces elevated total plasma levels of immunoglobulins, some of which recognize self- or parasite-specific antigens. To our knowledge, we are the first to report high levels of functional immunoglobulin E (IgE) autoantibodies recognizing brain 14-3-3 protein ε in asymptomatic P. falciparum malaria. 14-3-3 ε protein belongs to a family of proteins that binds to CD81, a member of the tetraspanin superfamily elicited in hepatocyte invasion by sporozoites. Levels of expression of 14-3-3 ε protein were found to be increased in vivo and in vitro during Plasmodium yoelii and P. falciparum intrahepatic development. Collectively, these results indicate that self-reactive IgE is produced during malaria. In addition, the negative correlation between levels of self-reactive IgE to 14-3-3 ε protein and parasitemia in asymptomatic malaria due to P. falciparum supports a role for these IgE molecules in defense mechanisms, probably by interfering with development of liver-stage parasites through the CD81 pathway.
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| Authors | Joana Duarte, Fabien Herbert, Vincent Guiyedi, Jean-François Franetich, Jacques Roland, Pierre-André Cazenave, Dominique Mazier, Maryvonne Kombila, Constantin Fesel, Sylviane Pied |
| Journal | The Journal of infectious diseases (J Infect Dis) Vol. 206 Issue 11 Pg. 1781-9 (Dec 01 2012) ISSN: 1537-6613 [Electronic] United States |
| PMID | 22984113 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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