Abstract |
In nine anesthetized and ventilated swine, a microcomputer calculated cardiac output, venous admixture (Qsp/Qt) and physiologic deadspace (VD/VT) every 20 sec, utilizing dual oximetry and a gas exchange analyzer. After lung injury with ethchlorvynol (ECV), animals were bled 40% blood volume over 40 min. Mean cardiac output decreased 7.0 to 2.2 L/min (p less than .05) accompanied by a decrease in mean Qsp/Qt from 0.28 to 0.14 (p less than .05) and an increase in mean VD/VT from 0.39 to 0.54 (p less than .05). Arterial Hgb saturation (Sao2) increased from 88 +/- 7% to 90 +/- 6%. On regression of all data points for each variable, Qsp/Qt had a positive correlation with cardiac output (r = .90), mean arterial pressure (MAP, r = .87), mean pulmonary artery pressure (MPAP, r = .86), and mixed venous Hgb saturation (Svo2, r = .89, p less than .001). VD/VT had an inverse correlation with cardiac output (r = -.90), MAP (r = -.82), Qsp/Qt (r = -.83), MPAP (r = -.77), and Svo2 (r = -.92, p less than .001). The decreasing Qsp/Qt and increasing VD/VT, with decreasing pulmonary perfusion pressures, were attributed to selective loss of perfusion to alveoli with low ventilation/perfusion ratios.
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Authors | G D Kamal, T Symreng, D J Tatman, P J Jebson |
Journal | Critical care medicine
(Crit Care Med)
Vol. 18
Issue 2
Pg. 208-12
(Feb 1990)
ISSN: 0090-3493 [Print] United States |
PMID | 2298014
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Ethchlorvynol
(poisoning)
- Lung Diseases
(chemically induced, physiopathology)
- Microcomputers
- Monitoring, Physiologic
- Oximetry
- Shock
(physiopathology)
- Swine
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