Abstract | BACKGROUND: The aim of this study was to investigate the effect and the potential molecular mechanism of sustained inflation (SI) recruitment maneuvers in acute respiratory distress syndrome (ARDS) in beagle dog following endotracheal suctioning. METHODS: ARDS was induced in 24 beagle dogs with oleic acid. They had mechanical ventilation support. They were randomized into four groups after the establishment of the ARDS model: non-SI-open group where no SI was applied in beagle dogs with ARDS following open endotracheal suctioning; non-SI-closed group where no SI was applied in beagle dogs with ARDS following closed endotracheal suctioning; SI-open group where SI was applied in beagle dogs with ARDS following open endotracheal suctioning; and SI-closed group where SI was applied in beagle dogs with ARDS following closed endotracheal suctioning. Oxygenation, indexes of respiratory mechanics, and hemodynamic indexes were serially measured during the procedure. The serum protein level, or the messenger RNA in the heart and lung, of inflammation-related cytokines was investigated. RESULTS: CONCLUSION: SI in ARDS could improve oxygenation, lung compliance, and airway resistance, which was related to the improved degree of inflammation and better maintained aquaporins.
|
Authors | Feng Zhao, Wei Wang, Yong Fang, Xiantao Li, Lei Shen, Tongwa Cao, Hechen Zhu |
Journal | The journal of trauma and acute care surgery
(J Trauma Acute Care Surg)
Vol. 73
Issue 5
Pg. 1106-13
(Nov 2012)
ISSN: 2163-0763 [Electronic] United States |
PMID | 22976418
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Aquaporins
- Cytokines
- Inflammation Mediators
- RNA, Messenger
|
Topics |
- Airway Resistance
(physiology)
- Animals
- Aquaporins
(genetics, metabolism)
- Cytokines
(genetics, metabolism)
- Disease Models, Animal
- Dogs
- Inflammation Mediators
(metabolism)
- Intubation, Intratracheal
- Lung Compliance
(physiology)
- Male
- Myocardium
(metabolism)
- Positive-Pressure Respiration
(methods)
- RNA, Messenger
(metabolism)
- Respiratory Distress Syndrome
(etiology, metabolism, therapy)
- Respiratory Mechanics
(physiology)
- Suction
|