Conservative surgery, external radiotherapy, and HDR brachytherapy in a single fraction of 7 Gy in early breast cancer: long-term toxicity and esthetic assessment.

Abstract

INTRODUCTION:

The essential issue in conservative treatment is the quality in breast preservation. When risk factors for local relapse exist, a tumour bed boost is required, but the boost choice remains controversial. Prospectively, we studied long-term toxicity, cosmetic outcome and prognostic factors.

MATERIALS AND METHODS:

After conservative treatment, 115 patients received a single dose of 7 Gy HDR-brachytherapy (HDR-BT) boost between June 1996 and December 2005. Late toxicity was assessed using the LENT-SOMA scale. For esthetic assessment, a subjective scale was used for patients and a modified Fehlauer scale for physicians. Mean age was 56.6 years. Invasive ductal carcinoma (78 %) and lumpectomy (60 %) were predominantly reported. 48 % received chemotherapy (CT).

RESULTS:

Regarding toxicity, 39 % of patients reported breast pain, 75 % fibrosis, 56 % telangiectasias, 19 % lymphoedema, and 51 % retraction/atrophy. Concerning management, 22 % of patients with pain and 45 % with lymphoedema were treated. The esthetic result was found satisfactory by 96 % of the patients and 85 % of the physicians. Fibrosis was influenced by CT and a larger irradiated volume and telangiectasias by a greater implant volume.

CONCLUSIONS:

HDR-BT boost shows good cosmetic effects with acceptable toxicity. Patients overestimate the esthetic outcome. LENT/SOMA is useful to assess chronic toxicity.

• Authors: Aurora Rodríguez Pérez, Maria Concepción López Carrizosa, Pilar Maria Samper Ots, José Fermín Pérez-Regadera Gómez, José Zapatero Ortuño, Juan de Dios Sáez Garrido, Manuel Joaquín Martín de Miguel
• Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (Clin Transl Oncol) Vol. 14 Issue 12 Pg. 953-60 (Dec 2012) ISSN: 1699-3055 [Electronic] Italy
• PMID: 22975899 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Brachytherapy (adverse effects)
• Breast (pathology, radiation effects, surgery)
• Breast Neoplasms (pathology, radiotherapy, surgery)
• Dose Fractionation, Radiation
• Female
• Humans
• Mastectomy, Segmental
• Middle Aged
• Prospective Studies
• Treatment Outcome