Abstract | AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug ( NSAID)-related and idiopathic gastric ulcers. METHODS: We randomly selected 92 patients with H. pylori-associated ( n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, and for mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION:
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Authors | Doron Boltin, Marisa Halpern, Zohar Levi, Alex Vilkin, Sara Morgenstern, Samuel B Ho, Yaron Niv |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 18
Issue 33
Pg. 4597-603
(Sep 07 2012)
ISSN: 2219-2840 [Electronic] United States |
PMID | 22969235
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Gastric Mucins
- MUC5AC protein, human
- MUC6 protein, human
- Mucin 5AC
- Mucin-6
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects)
- CD4-CD8 Ratio
- Female
- Gastric Mucins
(metabolism)
- Gastric Mucosa
(metabolism, pathology)
- Helicobacter Infections
(complications)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Mucin 5AC
(metabolism)
- Mucin-6
(metabolism)
- T-Lymphocytes
(pathology)
- Ulcer
(chemically induced, metabolism, microbiology)
- Young Adult
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