Abstract |
Doses of d-amphetamine (3.2 mg/kg), fenfluramine (10 mg/kg) and quipazine (8 mg/kg) cause a significant reduction in food intake during a 30-min daily feeding session in food-deprived rats. Pirenperone and ritanserin, 5-HT2 receptor antagonists, significantly blocked the anorectic effect of quipazine, while d-amphetamine and fenfluramine effects were not modified. Metergoline, a non-specific blocker of 5-HT receptors, significantly blocked the anorectic effects of fenfluramine and quipazine, but not the d-amphetamine effect. Pretreatment with alpha- and beta-adrenergic receptor antagonists ( prazosin, propranolol and pindolol), dopamine receptor antagonists ( haloperidol and pimozide), the catecholamine synthesis inhibitor alpha-methyl-para-tyrosine, and the opioid receptor antagonist naloxone failed to modify the anorectic effects of all three agents, with the exception that quipazine-induced anorexia was significantly reduced by pimozide. These results suggest that the quipazine anorexia is largely mediating through 5-HT2 receptors, although the effect of pimozide remains to be explained. Consistent with previous studies, the fenfluramine effect appears to be mediated through 5-HT1B receptors. Receptors involved in the anorectic effect of higher doses of d-amphetamine are still unidentified by this analysis. Further investigation is required to define the mechanisms by which quipazine and larger doses of d-amphetamine bring about a reduced appetite for food.
|
Authors | R Shukla, D MacKenzie-Taylor, R H Rech |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 100
Issue 1
Pg. 115-8
( 1990)
ISSN: 0033-3158 [Print] Germany |
PMID | 2296618
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Appetite Depressants
- Quinolines
- Receptors, Serotonin
- Fenfluramine
- Quipazine
- Amphetamine
|
Topics |
- Amphetamine
(pharmacology)
- Animals
- Appetite Depressants
- Eating
(drug effects)
- Fenfluramine
(pharmacology)
- Male
- Quinolines
(pharmacology)
- Quipazine
(pharmacology)
- Rats
- Rats, Inbred Strains
- Receptors, Serotonin
(drug effects, physiology)
|