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Long-pulse Nd:YAG 1064-nm laser treatment for onychomycosis.

AbstractBACKGROUND:
Recent research shows that lasers can inhibit fungal growth and that Nd:YAG 1064-nm lasers can penetrate as deep as the lower nail plate. The aim of this study was to observe the effect of a long-pulse Nd:YAG 1064-nm laser on 154 nails of 33 patients with clinically and mycologically proven onychomycosis.
METHODS:
Thirty-three patients with 154 nails affected by onychomycosis were randomly assigned to two groups, with the 154 nails divided into three sub-groups (II degree, III degree, and IV degree) according to the Scoring Clinical Index of Onychomycosis. The 15 patients (78 nails) in group 1 were given eight sessions with a one-week interval, and the 18 patients (76 nails) in group 2 were given four sessions with a one-week interval.
RESULTS:
In group 1, the effective rates at 8 weeks, 16 weeks, and 24 weeks were 63%, 62%, and 51%, respectively, and the effective rates in group 2 were 68%, 67%, and 53% respectively. The treatment effect was not significantly different between any sub-group pair (P > 0.05).
CONCLUSIONS:
Long pulse Nd:YAG 1064-nm laser was effective for onychomycosis. It is a simple and effective method without significant complications or side effects and is expected to become an alternative or replacement therapy for onychomycosis.
AuthorsRui-na Zhang, Dong-kun Wang, Feng-lin Zhuo, Xiao-han Duan, Xiao-yan Zhang, Jun-ying Zhao
JournalChinese medical journal (Chin Med J (Engl)) Vol. 125 Issue 18 Pg. 3288-91 (Sep 2012) ISSN: 2542-5641 [Electronic] China
PMID22964325 (Publication Type: Journal Article, Randomized Controlled Trial)
Topics
  • Adolescent
  • Adult
  • Aged
  • Female
  • Humans
  • Lasers, Solid-State (therapeutic use)
  • Male
  • Middle Aged
  • Onychomycosis (surgery)
  • Young Adult

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