Abstract | UNLABELLED: What is already known about this subject Circulating concentrations of branched-chain amino acids (BCAAs) can affect carbohydrate metabolism in skeletal muscle, and therefore may alter insulin sensitivity. BCAAs are elevated in adults with diet-induced obesity, and are associated with their future risk of type 2 diabetes even after accounting for baseline clinical risk factors. What this study adds Increased concentrations of BCAAs are already present in young obese children and their metabolomic profiles are consistent with increased BCAA catabolism. Elevations in BCAAs in children are positively associated with insulin resistance measured 18 months later, independent of their initial body mass index. BACKGROUND: OBJECTIVE: METHODS: Sixty-nine healthy subjects, ages 8-18 years, were enrolled as a cross-sectional cohort. A subset of subjects who were pre- or early-pubertal, ages 8-13 years, were enrolled in a prospective longitudinal cohort for 18 months (n = 17 with complete data). RESULTS: Elevations in the concentrations of BCAAs were significantly associated with body mass index (BMI) Z-score (Spearman's Rho 0.27, P = 0.03) in the cross-sectional cohort. In the subset of subjects that followed longitudinally, baseline BCAA concentrations were positively associated with homeostasis model assessment for insulin resistance measured 18 months later after controlling for baseline clinical factors including BMI Z-score, sex and pubertal stage (P = 0.046). CONCLUSIONS: Elevations in the concentrations of circulating BCAAs are significantly associated with obesity in children and adolescents, and may independently predict future insulin resistance.
|
Authors | S E McCormack, O Shaham, M A McCarthy, A A Deik, T J Wang, R E Gerszten, C B Clish, V K Mootha, S K Grinspoon, A Fleischman |
Journal | Pediatric obesity
(Pediatr Obes)
Vol. 8
Issue 1
Pg. 52-61
(Feb 2013)
ISSN: 2047-6310 [Electronic] England |
PMID | 22961720
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | © 2012 The Authors. Pediatric Obesity © 2012 International Association for the Study of Obesity. |
Chemical References |
- Amino Acids, Branched-Chain
- Biomarkers
- Blood Glucose
- Insulin
- Isoleucine
- Leucine
- Valine
|
Topics |
- Adolescent
- Amino Acids, Branched-Chain
(blood)
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Body Mass Index
- Child
- Child Nutrition Disorders
(blood, epidemiology, prevention & control)
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(blood, epidemiology, prevention & control)
- Fasting
(blood)
- Female
- Humans
- Insulin
(blood, metabolism)
- Insulin Resistance
- Insulin Secretion
- Isoleucine
(blood)
- Leucine
(blood)
- Longitudinal Studies
- Male
- Massachusetts
(epidemiology)
- Obesity
(blood, epidemiology, etiology, prevention & control)
- Predictive Value of Tests
- Valine
(blood)
|