Abstract | BACKGROUND: METHODS: Consecutive women undergoing implant-assisted or extended autologous LD flap reconstruction were randomized to either standard care or application of fibrin sealant to the donor-site chest wall. All participants were blinded for the study duration but assessors were only partially blinded. Non-parametric methods were used for analysis. RESULTS: A total of 107 women were included (sealant 54, control 53). Overall back seroma volumes were high, with no significant differences between control and sealant groups over 3 months. Fibrin sealant failed to reduce in situ back drainage volumes in the 10 days after surgery, and did not affect the rate or volume of seromas following drain removal. CONCLUSION: This randomized study, which was powered for size effect, failed to show any benefit from fibrin sealant in minimizing back seromas after LD procedures.
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Authors | R Llewellyn-Bennett, R Greenwood, J R Benson, R English, J Turner, Z Rayter, Z E Winters |
Journal | The British journal of surgery
(Br J Surg)
Vol. 99
Issue 10
Pg. 1381-8
(Oct 2012)
ISSN: 1365-2168 [Electronic] England |
PMID | 22961517
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Chemical References |
- Fibrin Tissue Adhesive
- Tissue Adhesives
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Topics |
- Adult
- Aged
- Back
- Breast Neoplasms
(surgery)
- Female
- Fibrin Tissue Adhesive
(therapeutic use)
- Hematoma
(etiology)
- Humans
- Mammaplasty
(adverse effects, methods)
- Mastectomy
(methods)
- Middle Aged
- Necrosis
(etiology)
- Prospective Studies
- Seroma
(etiology, prevention & control)
- Surgical Flaps
- Surgical Wound Dehiscence
(etiology)
- Surgical Wound Infection
(etiology)
- Tissue Adhesives
(therapeutic use)
- Treatment Outcome
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