Radiotherapy for pleomorphic adenoma.

Abstract

PURPOSE:

The aim of this study was to update our experience in treating pleomorphic adenoma with radiotherapy (RT).

MATERIALS AND METHODS:

This is a retrospective analysis of 25 patients treated with RT alone (2 patients) or combined with surgery (23 patients), with follow-up ranging from 1.8 to 34.9 years (median, 10.5 years).

RESULTS:

Local control was achieved in 13 (75%) of 16 patients with subclinical disease and 5 (56%) of 9 patients with gross disease. Overall local control was achieved in 18 (72%) of 25 patients. The 5-, 10-, and 15-year overall local control rates were 76 %, 76%, and 68%, respectively. Ten patients died of the following causes: recurrent disease, 2; malignant transformation, 2; and intercurrent disease, 6. At last follow-up, 14 patients were alive without evidence of disease, and 1 patient was alive with disease. Dental carries and transient facial nerve deficits were the most common complications. No patients developed severe complications subsequent to RT.

CONCLUSIONS:

In patients at high risk for developing recurrent pleomorphic adenoma after surgery, RT is effective in controlling subclinical disease.

• Authors: Audrey S Wallace, Christopher G Morris, Jessica M Kirwan, John W Werning, William M Mendenhall
• Journal: American journal of otolaryngology (Am J Otolaryngol) 2013 Jan-Feb Vol. 34 Issue 1 Pg. 36-40 ISSN: 1532-818X [Electronic] United States
• PMID: 22959365 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Topics

• Adenoma, Pleomorphic (pathology, radiotherapy)
• Adult
• Aged
• Disease-Free Survival
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local
• Radiation Dosage
• Retrospective Studies
• Salivary Gland Neoplasms (pathology, radiotherapy)
• Time Factors
• Treatment Outcome