HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Is exercise training beneficial for heart failure patients taking β-adrenergic blockers? A systematic review and meta-analysis.

Abstract
The authors sought to conduct a systematic review comparing the effects of exercise training in heart failure patients taking β-blockers vs those not. A systematic search of exercise training trials in chronic heart failure patients that compared groups who took β-blocker medication or compared selective and nonselective β-blockers during exercise training was conducted. Eight prospective studies met the criteria for the quantitative synthesis, which included data from 236 participants. The increment in peak oxygen consumption (VO(2)) was greater in exercising vs control participants, with a mean difference (MD) of 1.27 mL/kg/min (95% confidence interval [CI], 0.85-1.70; P<.00001). In exercising patients, the increment in peak VO(2) was greater in the group taking β-blocker vs those taking placebo (MD, 1.66 mL/kg/min; 95% CI, 0.36-2.97; P=.01). In exercising patients, there was no difference in the increment of peak VO(2) between nonselective β-blocker and selective β-blockers groups (MD, -0.09 mL/kg/min; 95% CI, -1.54-1.36; P=.09). Minnesota Quality of Life Score was significantly better in the exercise group vs sedentary control group (both groups taking β-blockers) (MD, -11.3; 95% CI, -15.9 to -6.8; P<.00001). Our analysis demonstrated that β-adrenergic blocker therapy did not reduce exercise capacity or exercise training adaptations and quality of life in heart failure patients.
AuthorsHashbullah Ismail, James McFarlane, Neil A Smart
JournalCongestive heart failure (Greenwich, Conn.) (Congest Heart Fail) 2013 Mar-Apr Vol. 19 Issue 2 Pg. 61-9 ISSN: 1751-7133 [Electronic] United States
PMID22958534 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
Copyright© 2012 Wiley Periodicals, Inc.
Chemical References
  • Adrenergic beta-Antagonists
Topics
  • Adrenergic beta-Antagonists (therapeutic use)
  • Comparative Effectiveness Research
  • Exercise Therapy (methods)
  • Exercise Tolerance (drug effects)
  • Heart Failure (drug therapy, metabolism, physiopathology, psychology)
  • Humans
  • Oxygen Consumption (drug effects)
  • Patient Outcome Assessment
  • Quality of Life
  • Randomized Controlled Trials as Topic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: