Abstract | INTRODUCTION AND HYPOTHESIS: The aim of the study was to describe effectiveness and safety of percutaneous tibial nerve stimulation (PTNS) at 2 years in women with overactive bladder (OAB) syndrome unresponsive to pharmacotherapy. METHODS: Of 30 women who had initial positive response to PTNS, 23 continued to receive maintenance treatment and were reassessed at 2 years using bladder symptom diaries and the Incontinence Impact Questionnaire (IIQ-7). They were also questioned on acceptability and any adverse effects of long-term peripheral neuromodulative treatment. RESULTS: Data from 23 women were available and 7 had been lost to follow-up. With maintenance treatment, the median nocturnal frequency at 2 years had decreased by 57 % (3.5 to 1.5 times/night), while the median IIQ-7 had reduced from 30.4 to 21.5 (both p<0.01) compared to pre-treatment baseline. Median nocturnal frequency and IIQ-7 scores at 2 years were comparable to those documented after initial response to treatment at 6 weeks, suggesting that maintenance therapy continued to suppress OAB symptoms. Daytime frequency and daily urgency incontinence episodes at 2 years were statistically similar to those documented at 6 weeks and remained lower than pre-treatment baseline (6.5 vs 11.8 and 2.0 vs 3.5, respectively, p<0.05). The women received a median of 8.42 treatments per year and the median length between treatments was 64.3 days. Apart from hypaesthesia in the toe of one responder lasting for 4 months, there were no reported side effects. CONCLUSIONS: Women receiving PTNS for intractable OAB syndrome reported significant symptom relief at 2 years. This remains a safe mode of second-line treatment with excellent durability.
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Authors | W Yoong, P Shah, R Dadswell, L Green |
Journal | International urogynecology journal
(Int Urogynecol J)
Vol. 24
Issue 5
Pg. 795-9
(May 2013)
ISSN: 1433-3023 [Electronic] England |
PMID | 22955253
(Publication Type: Journal Article)
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Topics |
- Female
- Follow-Up Studies
- Humans
- Tibial Nerve
- Tibial Neuropathy
(etiology)
- Transcutaneous Electric Nerve Stimulation
(adverse effects)
- Treatment Outcome
- Urinary Bladder, Overactive
(therapy)
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