Schizonepeta tenuifolia inhibits the development of atopic dermatitis in mice.

Abstract

Historically, Schizonepeta tenuifolia (ST) has been used for the treatment of skin disorders, such as allergic dermatitis, eczema, and inflammatory diseases. In this study, we examined whether ST inhibited 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) in BALB/c mice. In histopathological analyses of the epidermis and dermis, skin thickness was significantly increased in DNCB-induced mice as compared with normal group. Treatment with ST inhibited this inflammatory change and markedly suppressed the secretion of immunoglobulin E, tumor necrosis factor α, and interleukin 6 levels in the serum of DNCB-induced mice. In addition, ST treatment significantly restored the upregulation of proinflammatory factors, such as nuclear factor (NF)-κB and mitogen-activated protein kinase expression. Taken together, due to its ability to suppress inflammatory factors and upregulate proinflammatory factors, ST may be useful as a therapeutic treatment for AD. ST extract application decreased both epidermis and dermis thickness in DNCB-induced mice. In serum, ST reduced immunoglobulin E, tumor necrosis factor, and interleukin 6 level. In addition, ST suppressed NF-κB activation as well as the mitogen-activated protein kinase activities.

• Authors: You Yeon Choi, Mi Hye Kim, Jong-Hyun Kim, Hyuk-Sang Jung, Youngjoo Sohn, Young Jin Choi, Man Ki Hwang, Sung-Hoon Kim, Jinju Kim, Woong Mo Yang
• Journal: Phytotherapy research : PTR (Phytother Res) Vol. 27 Issue 8 Pg. 1131-5 (Aug 2013) ISSN: 1099-1573 [Electronic] England
• PMID: 22949410 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 John Wiley & Sons, Ltd.

Chemical References

• Anti-Inflammatory Agents
• Dinitrochlorobenzene
• Interleukin-6
• NF-kappa B
• Plant Extracts
• Tumor Necrosis Factor-alpha
• Immunoglobulin E
• Mitogen-Activated Protein Kinases

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Dermatitis, Atopic (chemically induced, drug therapy)
• Dinitrochlorobenzene
• Disease Models, Animal
• Female
• Immunoglobulin E (blood)
• Interleukin-6 (blood)
• Lamiaceae (chemistry)
• Mice
• Mice, Inbred BALB C
• Mitogen-Activated Protein Kinases (metabolism)
• NF-kappa B (metabolism)
• Plant Extracts (pharmacology)
• Skin (drug effects)
• Tumor Necrosis Factor-alpha (blood)