Abstract | AIM: SUBJECTS AND METHODS: Twenty-four patients with left-hemispheric stroke and aphasia were subjected. During 11-day hospitalization, each patient received 10 treatment sessions consisting of 40-min 1-Hz LF-rTMS and 60-min intensive ST, excluding Sundays. The scalp area for stimulation was selected based on the findings of fMRI with language tasks and the type of aphasia. LF-rTMS was applied to the inferior frontal gyrus (IGF) for patients with nonfluent aphasia and to the superior temporal gyrus (STG) for patients with fluent aphasia. RESULTS: On pretreatment fMRI, the most activated areas were in the left hemisphere (n=16) and right hemisphere (n=8). The types of aphasia were nonfluent (n=14) and fluent (n=10). The LF-rTMS was applied to the right STG (n=5), left STG (n=5), right IFG (n=11) and left IFG (n=3). Nonfluent aphasic patients showed significant improvement of auditory comprehension, reading comprehension and repetition. Fluent aphasic patients showed significant improvement in spontaneous speech only. CONCLUSION: The fMRI with aphasic type-based therapeutic LF-rTMS/intensive ST for chronic aphasia seems feasible and a potentially useful neurorehabilitative protocol.
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Authors | Masahiro Abo, Wataru Kakuda, Motoi Watanabe, Azusa Morooka, Katsuya Kawakami, Atsushi Senoo |
Journal | European neurology
(Eur Neurol)
Vol. 68
Issue 4
Pg. 199-208
( 2012)
ISSN: 1421-9913 [Electronic] Switzerland |
PMID | 22948550
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Topics |
- Adult
- Aged
- Aphasia
(etiology, rehabilitation)
- Brain Mapping
- Female
- Humans
- Magnetic Resonance Imaging
(methods)
- Male
- Middle Aged
- Pilot Projects
- Speech Therapy
(methods)
- Stroke
(complications)
- Stroke Rehabilitation
- Transcranial Magnetic Stimulation
(methods)
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