Abstract | AIM: METHODS: Fifteen Wistar albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal edema and corneal opacity scores were assessed. RESULTS: The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal edema and opacity scores were significantly lower in both study groups compared to the control group (P<0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. CONCLUSION:
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Authors | Ayhan Dursun, Mustafa Kemal Arici, Feyza Dursun, Ayse Vural Ozec, Mustafa Ilker Toker, Haydar Erdogan, Aysen Topalkara |
Journal | International journal of ophthalmology
(Int J Ophthalmol)
Vol. 5
Issue 4
Pg. 448-51
( 2012)
ISSN: 2227-4898 [Electronic] China |
PMID | 22937503
(Publication Type: Journal Article)
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