Abstract | OBJECTIVE: HYPOTHESIS: STUDY DESIGN: Retrospective review. SETTING: INTERVENTIONS: MAIN OUTCOME MEASURES: Bone conduction pure tone threshold averages (PTAs) and word recognition (WR) scores were examined for each ear before and after bisphosphonate treatment. Criteria for significant change were defined as greater than 10 decibels in PTA or between 4% and 18% in WR based on binomial variance. RESULTS: All 10 patients had audiometric progression of SNHL in the pretreatment monitoring interval and 12 ears met criteria for significant progression. All 10 patients (19 ears) showed at least no significant progression of SNHL (i.e., stabilization) at an average follow-up of 13 months. Two patients (3 ears) showed improvement by defined audiometric criteria. There were no major complications. CONCLUSION:
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Authors | Alicia M Quesnel, Margaret Seton, Saumil N Merchant, Christopher Halpin, Michael J McKenna |
Journal | Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
(Otol Neurotol)
Vol. 33
Issue 8
Pg. 1308-14
(Oct 2012)
ISSN: 1537-4505 [Electronic] United States |
PMID | 22935809
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Imidazoles
- Zoledronic Acid
- Risedronic Acid
- Etidronic Acid
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Topics |
- Adult
- Aged
- Audiometry, Pure-Tone
- Auditory Threshold
(physiology)
- Bone Conduction
(physiology)
- Bone Density Conservation Agents
(therapeutic use)
- Diphosphonates
(therapeutic use)
- Etidronic Acid
(analogs & derivatives, therapeutic use)
- Female
- Hearing Loss, Sensorineural
(drug therapy, etiology)
- Humans
- Imidazoles
(therapeutic use)
- Male
- Middle Aged
- Otosclerosis
(complications, drug therapy)
- Retrospective Studies
- Risedronic Acid
- Speech Perception
- Tomography, X-Ray Computed
- Treatment Outcome
- Zoledronic Acid
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