[Clinical study of correlation between the expression of ICBP90 and hematopoietic suppression in patients with chronic benzene poisoning].

Abstract

OBJECTIVE:

To observe the change of ICBP90 expression in patients with chronic benzene poisoning and explore the correlation between the expression of ICBP90 and benzene-induced hematotoxicity.

METHODS:

The bone marrow samples were from 13 chronic benzene poisoning cases with hematopoietic suppression, 11 chronic benzene poisoning cases with hematopoietic regeneration and 10 controls. Western-blot was applied to detect the ICBP90 expression in bone marrow mononuclear cells (BMNCs). The correlation between ICBP90 expression and hematopoietic suppression in patients with chronic benzene poisoning was analyzed.

RESULTS:

The ICBP90 expression of BMNCs in 13 chronic benzene poisoning cases with hematopoietic suppression was significantly lower than that in controls (P < 0.01). The ICBP90 expression of BMNCs in 11 chronic benzene poisoning cases with hematopoietic regeneration was significantly higher than those in controls and 13 chronic benzene poisoning cases with hematopoietic suppression (P < 0.05 or P < 0.01), respectively. There were good correlations between the expression of ICBP90 and white blood cell and platelet counts in patients with chronic benzene poisoning (r(1) = 0.555,P = 0.006; r(2) = 0.854,P < 0.01).

CONCLUSION:

The ICBP90 expression of BMNCs in the chronic benzene poisoning cases with hematopoietic suppression decreased significantly, and the ICBP90 expression of BMNCs in the chronic benzene poisoning cases with hematopoietic regeneration increased significantly. There was good correlation between hematopoietic suppression and ICBP90 expression in patients with chronic benzene poisoning.

• Authors: Sheng Luo, Xiao-yan Huang, Qian Hu, Xu-dong Hu, Chong-yun Xing, Kang Yu
• Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi) Vol. 30 Issue 8 Pg. 571-4 (Aug 2012) ISSN: 1001-9391 [Print] China
• PMID: 22931873 (Publication Type: Journal Article)

Chemical References

• CCAAT-Enhancer-Binding Proteins
• UHRF1 protein, human
• Ubiquitin-Protein Ligases
• Benzene

Topics

• Adult
• Benzene (poisoning)
• Blood Platelets (metabolism)
• Bone Marrow Cells (metabolism)
• CCAAT-Enhancer-Binding Proteins (metabolism)
• Case-Control Studies
• Female
• Hematopoiesis (drug effects)
• Humans
• Leukocytes (metabolism)
• Male
• Ubiquitin-Protein Ligases
• Young Adult