Metronidazole treatment for acute phase amoebic liver abscess in patients co-infected with HIV.

Abstract

Metronidazole is the drug of choice for invasive amoebiasis; however, it is not known whether its dose or duration require modification in HIV infection when treating invasive amoebiasis. Seven HIV-positive patients with acute phase amoebic liver abscess were treated with daily oral administration of 1500 mg of metronidazole for 10 days. None of the patients required abscess drainage, and metronidazole was effective in all patients without serious side-effects. The CD4 cell count or HIV viral load did not appear to influence the efficacy of metronidazole therapy.

• Authors: K Ohnishi, F Uchiyama-Nakamura
• Journal: International journal of STD & AIDS (Int J STD AIDS) Vol. 23 Issue 8 Pg. e1-3 (Aug 2012) ISSN: 1758-1052 [Electronic] England
• PMID: 22930307 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Amebicides
• Metronidazole

Topics

• AIDS-Related Opportunistic Infections (drug therapy, parasitology)
• Adult
• Amebicides (therapeutic use)
• CD4 Lymphocyte Count
• Humans
• Liver Abscess, Amebic (complications, drug therapy)
• Male
• Metronidazole (therapeutic use)
• Middle Aged
• Viral Load