Favourable outcome of progressive multifocal leukoencephalopathy with mefloquine treatment in combination with antiretroviral therapy in an HIV-infected patient.

Abstract

A 33-year-old man who developed progressive multifocal leukoencephalopathy (PML) with HIV infection is reported. The patient exhibited rapid decline in neurological status after initiation of antiretroviral therapy (ART), which was attributed to the PML-immune re-constitution inflammatory syndrome. Following the administration of mefloquine in combination with ART, the patient's neurological status improved substantially. This case suggests that further investigation of the use of mefloquine might be warranted for treatment of PML in HIV-infected patients.

• Authors: E Adachi, T Koibuchi, K Imai, T Kikuchi, M Koga, H Nakamura, T Miura, A Iwamoto, T Fujii
• Journal: International journal of STD & AIDS (Int J STD AIDS) Vol. 23 Issue 8 Pg. 603-5 (Aug 2012) ISSN: 1758-1052 [Electronic] England
• PMID: 22930304 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-HIV Agents
• Antiviral Agents
• Mefloquine

Topics

• AIDS-Related Opportunistic Infections (drug therapy)
• Adult
• Anti-HIV Agents (administration & dosage, therapeutic use)
• Antiviral Agents (administration & dosage, therapeutic use)
• Brain (pathology, virology)
• Humans
• JC Virus (drug effects)
• Leukoencephalopathy, Progressive Multifocal (drug therapy, pathology)
• Magnetic Resonance Imaging
• Male
• Mefloquine (administration & dosage, therapeutic use)
• Neuroimaging