Differential effects of hGH and IGF-I on body proportions.

Abstract

UNLABELLED:

The differential growth effects of hGH and IGF-I on the upper/lower (U/L) body segment in relation to height (Ht) were analyzed in 15 patients with isolated Growth hormone deficiency (IGHD,:7M, 8F) mean age 5.0 +/- 3.2 (SD) years treated with hGH; 21 patients with multiple pituitary hormone deficiency including growth hormone (MPHD: 14M, 7F) aged 10.0 +/- 3.8, treated with hGH; 9 patients with Laron Syndrome (LS) (4M,5F) aged 6.9 +/- 5.6 years treated with IGF-I; 9 boys with intrauterine growth retardation (IUGR) aged 6.3 +/- 1.25 years treated by hGH; and 22 boys with idiopathic short stature (ISS) aged 8.0 +/- 1.55 years treated by hGH. The dose of hGH was 33 microg/kg/day, that of IGF-I 180-200 microg/kg/day.

RESULTS:

the U/L body segment ratio in IGHD patients decreased from 2.3 +/- 0.7 to 1.1 +/- 0.7 (p <0.001), and the Ht SDS increased from -4.9 +/- 1.3 to 2.3 +/- 1 (p < 0.001) following treatment. In MPHD patients the U/L body segment decreased from 1.1 +/- 1.1 to -0.6 +/- 1.0 (p < 0.001), and the Ht SDS increased from -3.3 +/- 1.4 to -2.5 +/- 1.0 (p < 0.009). In the LS group the U/L body segment ratio did not change with IGF-I treatment but Ht improved from -6.1 +/- 1.3 to -4.6 +/- 1.2 (p < 0.001), The differential growth response of the children with IUGR and with ISS resembled that of the children with LS.

CONCLUSIONS:

hGH and IGF-I act differentially on the spine and limbs.

• Authors: Zvi Laron, Aviva Silbergeld, Rivka Kauli
• Journal: Anthropologischer Anzeiger; Bericht uber die biologisch-anthropologische Literatur (Anthropol Anz) Vol. 69 Issue 3 Pg. 255-9 (Jul 2012) ISSN: 0003-5548 [Print] Germany
• PMID: 22928349 (Publication Type: Journal Article)

Chemical References

• Pituitary Hormones
• Human Growth Hormone
• Insulin-Like Growth Factor I

Topics

• Adolescent
• Body Height (drug effects)
• Body Size (drug effects)
• Child
• Child, Preschool
• Female
• Fetal Growth Retardation
• Growth Disorders (drug therapy)
• Human Growth Hormone (administration & dosage, deficiency)
• Humans
• Infant
• Insulin-Like Growth Factor I (administration & dosage)
• Laron Syndrome (drug therapy)
• Male
• Pituitary Hormones (deficiency)