Abstract |
Seventeen patients undergoing tonsillectomy received cefpodoxime proxetil orally in a dose equivalent to 100 mg cefpodoxime 4, 7 or 12 h before operation. Plasma and tonsillar tissue concentrations of cefpodoxime were assayed by a microbiological method. Tonsillar tissue concentrations after 4 and 7 h were 0.24 and 0.09 mg/kg respectively--being 23% of the plasma concentration. The tonsillar tissue concentration after 12 h was less than 0.06 mg/kg. As the MIC for Streptococcus pyogenes is less than 0.06 mg/l, cefpodoxime proxetil may be of value in acute tonsillitis.
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Authors | P Gehanno, J M Andrews, F Ichou, E Sultan, B Lenfant |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 26 Suppl E
Pg. 47-51
(Dec 1990)
ISSN: 0305-7453 [Print] England |
PMID | 2292530
(Publication Type: Journal Article)
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Chemical References |
- Prodrugs
- cefpodoxime proxetil
- cefpodoxime
- Ceftizoxime
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Topics |
- Administration, Oral
- Adolescent
- Adult
- Ceftizoxime
(administration & dosage, analogs & derivatives, blood, metabolism, pharmacokinetics)
- Female
- Humans
- Male
- Middle Aged
- Palatine Tonsil
(metabolism)
- Prodrugs
(administration & dosage, pharmacokinetics)
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