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Concentrations of cefpodoxime in plasma and tonsillar tissue after a single oral dose of cefpodoxime proxetil.

Abstract
Seventeen patients undergoing tonsillectomy received cefpodoxime proxetil orally in a dose equivalent to 100 mg cefpodoxime 4, 7 or 12 h before operation. Plasma and tonsillar tissue concentrations of cefpodoxime were assayed by a microbiological method. Tonsillar tissue concentrations after 4 and 7 h were 0.24 and 0.09 mg/kg respectively--being 23% of the plasma concentration. The tonsillar tissue concentration after 12 h was less than 0.06 mg/kg. As the MIC for Streptococcus pyogenes is less than 0.06 mg/l, cefpodoxime proxetil may be of value in acute tonsillitis.
AuthorsP Gehanno, J M Andrews, F Ichou, E Sultan, B Lenfant
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 26 Suppl E Pg. 47-51 (Dec 1990) ISSN: 0305-7453 [Print] England
PMID2292530 (Publication Type: Journal Article)
Chemical References
  • Prodrugs
  • cefpodoxime proxetil
  • cefpodoxime
  • Ceftizoxime
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Ceftizoxime (administration & dosage, analogs & derivatives, blood, metabolism, pharmacokinetics)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Palatine Tonsil (metabolism)
  • Prodrugs (administration & dosage, pharmacokinetics)

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