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Incidence of and risk factors for postoperative nausea and vomiting at a Japanese Cancer Center: first large-scale study in Japan.

AbstractPURPOSE:
The first purpose of this study was to determine the incidence of postoperative nausea and/or vomiting (PONV) 0-48 h after anesthesia at a Japanese cancer center. The second purpose of this study was to collect information on PONV risk factors, independently, in the categories of patient-related, anesthesia-related, and surgery-related factors.
METHODS:
The frequency of nausea and vomiting was prospectively investigated from 0 to 48 h after anesthesia in 1645 patients (11-94 years of age) at a single medical institution. The occurrence of nausea and vomiting and the use of antiemetics were recorded up to 48 h after anesthesia. Patient-related, anesthesia-related, and surgery-related factors were also recorded and submitted to multiple logistic regression analysis to determine the relationship of these factors to nausea and vomiting.
RESULTS:
The incidences of nausea and vomiting from 0 to 24 h after anesthesia were 40 and 22 %, respectively. The incidences 24-48 h after anesthesia were 10 and 3 %, respectively. Female sex, previous history of PONV, prolonged anesthesia, and remifentanil use during surgery were identified as risk factors for both nausea and vomiting. The use of a volatile anesthetic, use of fentanyl during surgery, postoperative use of opioids, nonsmoking status, and drinking alcohol on 4 or fewer days per week were identified as risk factors for nausea alone.
CONCLUSION:
The incidence of and risk factors for PONV at a Japanese cancer center according to this study are comparable to those reported elsewhere.
AuthorsRyozo Morino, Makoto Ozaki, Osamu Nagata, Miyuki Yokota
JournalJournal of anesthesia (J Anesth) Vol. 27 Issue 1 Pg. 18-24 (Feb 2013) ISSN: 1438-8359 [Electronic] Japan
PMID22923285 (Publication Type: Journal Article)
Chemical References
  • Antiemetics
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anesthesia (adverse effects)
  • Antiemetics (therapeutic use)
  • Child
  • Cohort Studies
  • Female
  • Humans
  • Japan (epidemiology)
  • Logistic Models
  • Male
  • Middle Aged
  • Neoplasms (surgery)
  • Postoperative Nausea and Vomiting (drug therapy, epidemiology)
  • Prospective Studies
  • Risk Factors
  • Sex Factors
  • Treatment Outcome
  • Young Adult

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