Abstract | PURPOSE: The first purpose of this study was to determine the incidence of postoperative nausea and/or vomiting ( PONV) 0-48 h after anesthesia at a Japanese cancer center. The second purpose of this study was to collect information on PONV risk factors, independently, in the categories of patient-related, anesthesia-related, and surgery-related factors. METHODS: The frequency of nausea and vomiting was prospectively investigated from 0 to 48 h after anesthesia in 1645 patients (11-94 years of age) at a single medical institution. The occurrence of nausea and vomiting and the use of antiemetics were recorded up to 48 h after anesthesia. Patient-related, anesthesia-related, and surgery-related factors were also recorded and submitted to multiple logistic regression analysis to determine the relationship of these factors to nausea and vomiting. RESULTS: The incidences of nausea and vomiting from 0 to 24 h after anesthesia were 40 and 22 %, respectively. The incidences 24-48 h after anesthesia were 10 and 3 %, respectively. Female sex, previous history of PONV, prolonged anesthesia, and remifentanil use during surgery were identified as risk factors for both nausea and vomiting. The use of a volatile anesthetic, use of fentanyl during surgery, postoperative use of opioids, nonsmoking status, and drinking alcohol on 4 or fewer days per week were identified as risk factors for nausea alone. CONCLUSION: The incidence of and risk factors for PONV at a Japanese cancer center according to this study are comparable to those reported elsewhere.
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Authors | Ryozo Morino, Makoto Ozaki, Osamu Nagata, Miyuki Yokota |
Journal | Journal of anesthesia
(J Anesth)
Vol. 27
Issue 1
Pg. 18-24
(Feb 2013)
ISSN: 1438-8359 [Electronic] Japan |
PMID | 22923285
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anesthesia
(adverse effects)
- Antiemetics
(therapeutic use)
- Child
- Cohort Studies
- Female
- Humans
- Japan
(epidemiology)
- Logistic Models
- Male
- Middle Aged
- Neoplasms
(surgery)
- Postoperative Nausea and Vomiting
(drug therapy, epidemiology)
- Prospective Studies
- Risk Factors
- Sex Factors
- Treatment Outcome
- Young Adult
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