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Aquaporin changes in compound 48/80 induced inflammatory sublaryngeal edema in rat.

AbstractOBJECTIVES/HYPOTHESIS:
Laryngeal edema is a common clinical condition. However, the underlying molecular mechanisms remain elusive. Aquaporins (AQPs) are small integral plasma membrane proteins that transport water across the plasma membrane. In this study, we explore the relationship between inflammatory laryngeal edema induced by compound 48/80 and the expression of AQPs.
STUDY DESIGN:
Prospective, controlled, experimental animal study.
METHODS:
Healthy adult male SD rats were injected with either sterile water, compound 48/80 (2 mg/kg), or compound 48/80 plus dexamethasone (3 mg/kg) via the tail vein. The larynxes were harvested 10, 30 minutes, and 1 hour after the injection for the measurement of sublaryngeal water content and histological and molecular evaluations.
RESULTS:
Ten and 30 minutes after the compound 48/80 injection compared with the sterile water injection control groups, the water content in subglottic larynx increased significantly and the tissues were markedly swollen accompanied with inflammatory cell infiltration. AQP1 and AQP5 mRNA decreased significantly. One hour after the compound 48/80 injection, the edema was diminished, but the inflammatory cell infiltration remained. AQP1 was elevated but AQP5 was still lower than controls. Dexamethasone did not significantly reduce laryngeal edema, but significantly reduced inflammatory cells infiltration induced by compound 48/80 injection. Dexamethasone increased the AQP5 level but not AQP1.
CONCLUSIONS:
AQP1 and AQP5 might play key roles in inflammatory subglottic edema caused by compound 48/80 in rats. AQP1 and AQP5 might be useful molecular targets of clinical treatment of inflammatory laryngeal edema.
AuthorsYongxin Liu, Huanjiu Xi, Weiwei Xing, Jingcheng Gu
JournalJournal of voice : official journal of the Voice Foundation (J Voice) Vol. 26 Issue 6 Pg. 815.e17-23 (Nov 2012) ISSN: 1873-4588 [Electronic] United States
PMID22921298 (Publication Type: Journal Article)
CopyrightCopyright © 2012 The Voice Foundation. Published by Mosby, Inc. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Aqp1 protein, rat
  • Aqp3 protein, rat
  • Aqp4 protein, rat
  • Aqp5 protein, rat
  • Aquaporin 4
  • Aquaporin 5
  • RNA, Messenger
  • Aquaporin 1
  • Aquaporin 3
  • p-Methoxy-N-methylphenethylamine
  • Dexamethasone
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Aquaporin 1 (genetics, metabolism)
  • Aquaporin 3 (metabolism)
  • Aquaporin 4 (metabolism)
  • Aquaporin 5 (genetics, metabolism)
  • Dexamethasone (pharmacology)
  • Disease Models, Animal
  • Edema (chemically induced, genetics, metabolism, prevention & control)
  • Gene Expression Regulation
  • Laryngitis (chemically induced, genetics, metabolism, prevention & control)
  • Larynx (drug effects, metabolism)
  • Male
  • RNA, Messenger (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors
  • p-Methoxy-N-methylphenethylamine

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