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Molecular-targeted therapies for ovarian cancer: prospects for the future.

Abstract
Ovarian cancer accounts for approximately 4 % of cancer deaths in women worldwide, with around 225,000 estimated new cases diagnosed each year and 140,000 related deaths. Prompt diagnosis is challenging because of the non-specific symptoms exhibited during the early stages of the disease; consequently, 50 % of cases present with advanced metastatic cancer, and 5-year survival rates are limited to 10-30 %. Furthermore, disease recurrence occurs in a high proportion of cases, and the survival rate is only 30 % even in patients who are sensitive to platinum-based chemotherapy. This review describes the increased characterization of the molecular mechanisms involved in the development and progression of ovarian cancer, and how this has resulted in improved therapeutic strategies with molecular-targeted agents. These include targeting BRCA mutations to affect DNA repair, inhibition of the mTOR and MAPK pathways, and anti-angiogenesis therapies. Ultimately, personalized therapy using novel biomarkers in parallel with improved early detection techniques could significantly enhance the prognosis of ovarian cancer patients.
AuthorsTamotsu Sudo
JournalInternational journal of clinical oncology (Int J Clin Oncol) Vol. 17 Issue 5 Pg. 424-9 (Oct 2012) ISSN: 1437-7772 [Electronic] Japan
PMID22915194 (Publication Type: Journal Article, Review)
Chemical References
  • TOR Serine-Threonine Kinases
  • Mitogen-Activated Protein Kinase Kinases
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Female
  • Genes, BRCA1
  • Humans
  • Mitogen-Activated Protein Kinase Kinases (antagonists & inhibitors, metabolism)
  • Models, Biological
  • Molecular Targeted Therapy (methods, trends)
  • Ovarian Neoplasms (drug therapy, genetics, pathology)
  • TOR Serine-Threonine Kinases (antagonists & inhibitors, metabolism)

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