Abstract | BACKGROUND: METHODS: Tissue from 36 patients with oropharyngeal SCC and 49 patients with oral cavity SCC treated between 1997 and 2001 was imbedded and immunostained using a tissue microarray. RESULTS: The p16 was positive in 57% and 13% of patients with oropharyngeal SCC and oral cavity SCC, respectively. EGFR was positive in 60% and 63% of patients with oropharyngeal SCC and oral cavity SCC, respectively. In patients with oropharyngeal SCC, p16 expression was associated with improved disease-specific survival (DSS), overall survival (OS), and time to recurrence (TTR) (p < .01, < .01, and <.01, respectively). EGFR expression was associated with poorer DSS, OS, and TTR (p < .01, = .01, and < .01, respectively). For oropharyngeal SCC, when examining both p16 and EGFR expression as combined biomarkers, high p16 expression coupled with low EGFR expression was associated with improved DSS (p p16 = .01; p EGFR = .01). Patients with oral cavity SCC showed no association between biomarker and outcome. CONCLUSIONS: For patients with oropharyngeal SCC, high p16 and low EGFR were associated with improved outcome, suggesting a predictive role in surgically treated patients.
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Authors | Shamir P Chandarana, Julia S Lee, Eric J P Chanowski, Assuntina G Sacco, Carol R Bradford, Gregory T Wolf, Mark E Prince, Jeffrey S Moyer, Avraham Eisbruch, Francis P Worden, Thomas J Giordano, Bhavna Kumar, Katrina G Cordell, Thomas E Carey, Douglas B Chepeha |
Journal | Head & neck
(Head Neck)
Vol. 35
Issue 8
Pg. 1083-90
(Aug 2013)
ISSN: 1097-0347 [Electronic] United States |
PMID | 22907805
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Wiley Periodicals, Inc. |
Chemical References |
- Biomarkers
- CDKN2A protein, human
- Cyclin-Dependent Kinase Inhibitor p16
- Neoplasm Proteins
- ErbB Receptors
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Topics |
- Adult
- Aged
- Biomarkers
(metabolism)
- Cohort Studies
- Cyclin-Dependent Kinase Inhibitor p16
- ErbB Receptors
(metabolism)
- Female
- Humans
- Male
- Middle Aged
- Mouth Neoplasms
(metabolism, mortality, surgery)
- Neoplasm Proteins
(metabolism)
- Oropharyngeal Neoplasms
(metabolism, mortality, surgery)
- Predictive Value of Tests
- Prevalence
- Survival Rate
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