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Advances in hepatitis immunization (A, B, E): public health policy and novel vaccine delivery.

AbstractPURPOSE OF REVIEW:
This review offers an update on hepatitis A, B and E vaccines based on relevant literature published in 2011-2012. Hepatitis A and B vaccines have been commercially available for years; however, the development of the hepatitis E vaccine is still facing some challenges.
RECENT FINDINGS:
Current scientific evidence shows that both hepatitis A and B vaccines confer long-term protection. These data supported the updated recommendations from the WHO on hepatitis A and B vaccines and the respective booster policy. In addition, a single-dose hepatitis A vaccination programme may be an option for some intermediate endemic countries, as far as the epidemiological situation is further monitored. Recent data illustrate the co-administration of hepatitis A with infant vaccines, as well as the interchangeability with other hepatitis A vaccines. Two genetically engineered hepatitis E vaccines are currently in development, showing more than 95% protective efficacy.
SUMMARY:
Follow-up of vaccinated individuals confirms the long-term protection offered by the hepatitis A as well as hepatitis B vaccines. Data confirm the safety and immunogenicity profile of both vaccines, also when used in patient groups. The first data on the hepatitis E vaccine look promising, but questions on cross-protection, long-term efficacy and safety and immunogenicity in pregnant women and children less than 2 years remain unanswered.
AuthorsGreet Hendrickx, Alex Vorsters, Pierre Van Damme
JournalCurrent opinion in infectious diseases (Curr Opin Infect Dis) Vol. 25 Issue 5 Pg. 578-83 (Oct 2012) ISSN: 1473-6527 [Electronic] United States
PMID22907280 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Hepatitis A Vaccines
  • Hepatitis B Vaccines
  • Vaccines, Combined
  • Viral Hepatitis Vaccines
Topics
  • Global Health
  • Health Policy
  • Hepatitis (prevention & control)
  • Hepatitis A (prevention & control)
  • Hepatitis A Vaccines (administration & dosage)
  • Hepatitis B (prevention & control)
  • Hepatitis B Vaccines (administration & dosage)
  • Hepatitis E (prevention & control)
  • Hepatitis E virus (immunology)
  • Humans
  • Immunization Programs (methods)
  • Vaccination (methods)
  • Vaccines, Combined (administration & dosage)
  • Viral Hepatitis Vaccines (administration & dosage)

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