Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Current scientific evidence shows that both hepatitis A and B vaccines confer long-term protection. These data supported the updated recommendations from the WHO on hepatitis A and B vaccines and the respective booster policy. In addition, a single-dose hepatitis A vaccination programme may be an option for some intermediate endemic countries, as far as the epidemiological situation is further monitored. Recent data illustrate the co-administration of hepatitis A with infant vaccines, as well as the interchangeability with other hepatitis A vaccines. Two genetically engineered hepatitis E vaccines are currently in development, showing more than 95% protective efficacy. SUMMARY: Follow-up of vaccinated individuals confirms the long-term protection offered by the hepatitis A as well as hepatitis B vaccines. Data confirm the safety and immunogenicity profile of both vaccines, also when used in patient groups. The first data on the hepatitis E vaccine look promising, but questions on cross-protection, long-term efficacy and safety and immunogenicity in pregnant women and children less than 2 years remain unanswered.
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Authors | Greet Hendrickx, Alex Vorsters, Pierre Van Damme |
Journal | Current opinion in infectious diseases
(Curr Opin Infect Dis)
Vol. 25
Issue 5
Pg. 578-83
(Oct 2012)
ISSN: 1473-6527 [Electronic] United States |
PMID | 22907280
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Hepatitis A Vaccines
- Hepatitis B Vaccines
- Vaccines, Combined
- Viral Hepatitis Vaccines
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Topics |
- Global Health
- Health Policy
- Hepatitis
(prevention & control)
- Hepatitis A
(prevention & control)
- Hepatitis A Vaccines
(administration & dosage)
- Hepatitis B
(prevention & control)
- Hepatitis B Vaccines
(administration & dosage)
- Hepatitis E
(prevention & control)
- Hepatitis E virus
(immunology)
- Humans
- Immunization Programs
(methods)
- Vaccination
(methods)
- Vaccines, Combined
(administration & dosage)
- Viral Hepatitis Vaccines
(administration & dosage)
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