Abstract | OBJECTIVES: METHODS: A total of 61 patients with AECOPD, 43 patients with CSCOPD and 20 healthy age-matched controls were included in the study. Circulating IGF-1 and CRP levels, together with erythrocyte sedimentation rate and indicators of malnutrition and muscle wasting, were measured in all the study participants. RESULTS: Circulating IGF-1 levels were significantly lower and CRP levels significantly higher in COPD patients than in controls. In addition, IGF-1 levels were significantly lower and CRP levels significantly higher in AECOPD patients than in CSCOPD patients. In COPD patients, indicators of malnutrition and muscle wasting ( weight, body mass index, thigh circumference and albumin level) were significantly positively correlated with logIGF-1; thigh circumference and albumin level were significantly inversely correlated with logCRP. CONCLUSION: Circulating IGF-1 and CRP levels may have potential as indicators of exacerbation, malnutrition and muscle wasting in patients with COPD.
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Authors | M Ye, H Yu, W Yu, G Zhang, L Xiao, X Zheng, J Wu |
Journal | The Journal of international medical research
(J Int Med Res)
Vol. 40
Issue 3
Pg. 1025-35
( 2012)
ISSN: 1473-2300 [Electronic] England |
PMID | 22906275
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Insulin-Like Growth Factor I
- C-Reactive Protein
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Topics |
- Aged
- Biomarkers
(blood)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Female
- Humans
- Insulin-Like Growth Factor I
(metabolism)
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
(blood, metabolism)
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