Abstract | OBJECTIVE: PATIENTS AND METHODS: From July 2008 to December 2010, all patients with AML treated using anthracycline and Ara-C combination therapy were registered in the study. This retrospective study investigated the patients' background and the incidence of CINV and constipation from the patients' records. The efficacy of granisetron was measured on each day using the complete regression(no vomiting and no rescue medication; CR)rate. RESULTS: A total of 45 patients were included in the study(27 male; 18 female), and received a total 68 courses(56 of induction therapy; 12 of consolidation therapy)of the regimens. The CR rate and the incidence of constipation on the final day of chemotherapy were 61. 8% and 63. 2%, respectively. As the duration of chemotherapy increased, the CR rate tended to decrease, whereas the incidence of constipation tended to increase. DISCUSSION:
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Authors | Takashi Goto, Kazuki Tanimoto, Makoto Ishibashi, Seiichi Okamura |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 39
Issue 8
Pg. 1227-32
(Aug 2012)
ISSN: 0385-0684 [Print] Japan |
PMID | 22902447
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anthracyclines
- Antiemetics
- Cytarabine
- Granisetron
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anthracyclines
(administration & dosage, adverse effects)
- Antiemetics
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Constipation
(chemically induced)
- Cytarabine
(administration & dosage, adverse effects)
- Female
- Granisetron
(therapeutic use)
- Humans
- Leukemia, Myeloid, Acute
(drug therapy)
- Male
- Middle Aged
- Nausea
(chemically induced, prevention & control)
- Retrospective Studies
- Vomiting
(chemically induced, prevention & control)
- Young Adult
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