Impact of infection or vaccination on pre-existing serological memory.

Abstract

Once established, serum antibody responses against a specific pathogen may last a lifetime. We describe a cohort of four subjects who received smallpox vaccination, and a single subject who received multiple vaccinations, with antibody levels to unrelated antigens monitored for 1-3 years. These immunizations provided the opportunity to determine if infection/vaccination and the resulting toll-like receptor stimulation would alter antigen-specific serological memory to other antigens, including bacterial toxins (tetanus, diphtheria, and pertussis) and viruses (yellow fever virus, measles, mumps, rubella, Epstein-Barr virus, and varicella-zoster virus). Our results indicate that serum IgG levels are remarkably stable and infection or vaccination are unlikely to increase or decrease pre-existing antigen-specific antibody responses.

• Authors: Ian J Amanna, Erika Hammarlund, Mathew W Lewis, Mark K Slifka
• Journal: Human immunology (Hum Immunol) Vol. 73 Issue 11 Pg. 1082-6 (Nov 2012) ISSN: 1879-1166 [Electronic] United States
• PMID: 22902392 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Viral
• Immunoglobulin G
• Vaccines

Topics

• Antibodies, Viral (blood, immunology)
• Antibody Formation (immunology)
• Humans
• Immunoglobulin G (blood, immunology)
• Immunologic Memory
• Infections (etiology, immunology)
• Vaccination
• Vaccines (immunology)
• Vaccinia (immunology)
• Vaccinia virus (immunology)