Abstract | BACKGROUND:
Pancreatic cancer is a distressing disease with a miserable prospects and early recognition remains a challenge due to ubiquitous symptomatic presentation, deep anatomical location, and aggressive etiology. False positives and problems in distinguishing pancreatitis from adenocarcinoma limit the use of CA 19-9 as both disorders can present with similar symptoms and share radiographic physiognomies. This study aimed to assess the relative increase in accuracy of diagnosing the patients with chronic pancreatitis, benign neoplasm of pancreas and adenocarcinomas with CA 19-9, haptoglobin, and serum amyloid A in comparison to CA 19-9 alone. MATERIALS AND METHODS: This hospital based case control study was carried out in the Departments of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal, between 1st January 2010 and 31st December 2011. The variables assessed were age, gender, serum CA19-9, serum haptoglobulin, serum Amyloid A. The data were analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. RESULTS: CONCLUSIONS: These statistics established that haptoglobin and SAA are useful in discriminating cancer from benign conditions as well as healthy controls.
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Authors | Mohammad Shamim Farooqui, Ankush Mittal, Bibek Poudel, Suhas Kumar Mall, Brijesh Sathian, Mohammad Tarique, Mohammad Hibban Farooqui |
Journal | Asian Pacific journal of cancer prevention : APJCP
(Asian Pac J Cancer Prev)
Vol. 13
Issue 5
Pg. 2171-4
( 2012)
ISSN: 2476-762X [Electronic] Thailand |
PMID | 22901189
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA-19-9 Antigen
- HP protein, human
- Haptoglobins
- Serum Amyloid A Protein
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Topics |
- Adenocarcinoma
(blood, diagnosis)
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- CA-19-9 Antigen
(blood)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Haptoglobins
(metabolism)
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Nepal
- Pancreas
(metabolism)
- Pancreatic Diseases
(blood, diagnosis)
- Prognosis
- Serum Amyloid A Protein
(metabolism)
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