hOGG1, p53 genes, and smoking interactions are associated with the development of lung cancer.

Abstract

This study aimed to investigate the effects of Ser/Cys polymorphism in hOGG1 gene, Arg/Pro polymorphism in p53 gene, smoking and their interactions on the development of lung cancer. Ser/Cys polymorphism in hOGG1 and Arg/Pro polymorphism in p53 among 124 patients with lung cancer and 128 normal people were detected using PCR-RFLP. At the same time, smoking status was investigated between the two groups. Logistic regression was used to estimate the effects of Ser/Cys polymorphism and Arg/Pro polymorphisms, smoking and their interactions on the development of lung cancer. ORs (95% CI) of smoking, hOGG1 Cys/Cys and p53 Pro/ Pro genotypes were 2.34 (1.41-3.88), 2.12 (1.03-4.39), and 2.12 (1.15-3.94), respectively. The interaction model of smoking and Cys/Cys was super-multiplicative or multiplicative, and the OR (95% CI) for their interaction item was 1.67 (0.36 -7.78). The interaction model of smoking and Pro/Pro was super-multiplicative with an OR (95%CI) of their interaction item of 5.03 (1.26-20.1). The interaction model of Pro/Pro and Cys/Cys was multiplicative and the OR (95%CI) of their interaction item was 0.99 (0.19-5.28). Smoking, hOGG1 Cys/Cys, p53 Pro/Pro and their interactions may be the important factors leading to the development of lung cancer.

• Authors: Zhe Cheng, Wei Wang, Yong-Na Song, Yan Kang, Jie Xia
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 13 Issue 5 Pg. 1803-8 ( 2012) ISSN: 2476-762X [Electronic] Thailand
• PMID: 22901126 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• TP53 protein, human
• Tumor Suppressor Protein p53
• DNA Glycosylases
• oxoguanine glycosylase 1, human

Topics

• Adenocarcinoma (etiology, pathology)
• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (etiology, pathology)
• Case-Control Studies
• DNA Glycosylases (genetics)
• Female
• Genetic Predisposition to Disease
• Genotype
• Humans
• Lung Neoplasms (etiology, pathology)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Restriction Fragment Length
• Polymorphism, Single Nucleotide (genetics)
• Prognosis
• Risk Factors
• Smoking (adverse effects)
• Tumor Suppressor Protein p53 (genetics)